Reaction Details |
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Target | Tyrosine-protein kinase Fyn |
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Ligand | BDBM25116 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1587936 (CHEMBL3826739) |
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IC50 | 27±n/a nM |
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Citation | Fraser, C; Dawson, JC; Dowling, R; Houston, DR; Weiss, JT; Munro, AF; Muir, M; Harrington, L; Webster, SP; Frame, MC; Brunton, VG; Patton, EE; Carragher, NO; Unciti-Broceta, A Rapid Discovery and Structure-Activity Relationships of Pyrazolopyrimidines That Potently Suppress Breast Cancer Cell Growth via SRC Kinase Inhibition with Exceptional Selectivity over ABL Kinase. J Med Chem59:4697-710 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosine-protein kinase Fyn |
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Name: | Tyrosine-protein kinase Fyn |
Synonyms: | FYN | FYN_HUMAN | Proto-oncogene Syn | Proto-oncogene c-Fyn | SLK | SRC | Src-like kinase | p59-Fyn |
Type: | Enzyme |
Mol. Mass.: | 60762.21 |
Organism: | Homo sapiens (Human) |
Description: | P06241 |
Residue: | 537 |
Sequence: | MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQG
LTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWW
EARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESET
TKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCC
RLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKT
LKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGR
ALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEY
TARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVE
RGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL
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BDBM25116 |
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n/a |
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Name | BDBM25116 |
Synonyms: | 1-tert-butyl-3-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | CHEMBL306380 | PP1 | US10688093, Compound PP1 (Pfizer) | US10807986, Comparative compound 1 | US11046696, Compound 1 of Comparative Examples | US11701353, PP1 (Pfizer) | cid_1400 |
Type | Small organic molecule |
Emp. Form. | C16H19N5 |
Mol. Mass. | 281.3556 |
SMILES | Cc1ccc(cc1)-c1nn(c2ncnc(N)c12)C(C)(C)C |
Structure |
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