| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase Yes |
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| Ligand | BDBM50184774 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1587942 (CHEMBL3824532) |
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| IC50 | 566±n/a nM |
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| Citation |  Fraser, C; Dawson, JC; Dowling, R; Houston, DR; Weiss, JT; Munro, AF; Muir, M; Harrington, L; Webster, SP; Frame, MC; Brunton, VG; Patton, EE; Carragher, NO; Unciti-Broceta, A Rapid Discovery and Structure-Activity Relationships of Pyrazolopyrimidines That Potently Suppress Breast Cancer Cell Growth via SRC Kinase Inhibition with Exceptional Selectivity over ABL Kinase. J Med Chem59:4697-710 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase Yes |
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| Name: | Tyrosine-protein kinase Yes |
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| Synonyms: | Proto-oncogene c-Yes | VHL/Tyrosine-protein kinase Yes | YES | YES1 | YES_HUMAN | p61-yes |
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| Type: | Protein |
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| Mol. Mass.: | 60801.54 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P07947 |
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| Residue: | 543 |
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| Sequence: | MGCIKSKENKSPAIKYRPENTPEPVSTSVSHYGAEPTTVSPCPSSSAKGTAVNFSSLSMT
PFGGSSGVTPFGGASSSFSVVPSSYPAGLTGGVTIFVALYDYEARTTEDLSFKKGERFQI
INNTEGDWWEARSIATGKNGYIPSNYVAPADSIQAEEWYFGKMGRKDAERLLLNPGNQRG
IFLVRESETTKGAYSLSIRDWDEIRGDNVKHYKIRKLDNGGYYITTRAQFDTLQKLVKHY
TEHADGLCHKLTTVCPTVKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTT
KVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEPIYIVTEFMSKGSLLDFL
KEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLVCKIADFGLARL
IEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNRE
VLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFLEDYFTATEPQYQPG
ENL
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| BDBM50184774 |
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| n/a |
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| Name | BDBM50184774 |
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| Synonyms: | CHEMBL3799221 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H21N7O2 |
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| Mol. Mass. | 367.405 |
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| SMILES | CCOC(Cn1nc(-c2cnc3[nH]ccc3c2)c2c(N)ncnc12)OCC |
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| Structure | 
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