Reaction Details |
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Target | Sphingosine-1-phosphate lyase 1 |
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Ligand | BDBM50018286 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1590337 (CHEMBL3830376) |
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IC50 | 94±n/a nM |
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Citation | Sanllehí, P; Abad, JL; Casas, J; Bujons, J; Delgado, A Bacterial versus human sphingosine-1-phosphate lyase (S1PL) in the design of potential S1PL inhibitors. Bioorg Med Chem24:4381-4389 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sphingosine-1-phosphate lyase 1 |
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Name: | Sphingosine-1-phosphate lyase 1 |
Synonyms: | KIAA1252 | S1PL | SGPL1 | SGPL1_HUMAN | SP-lyase 1 | SPL 1 | Sphingosine-1-phosphate aldolase | hSPL |
Type: | PROTEIN |
Mol. Mass.: | 63546.76 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_108363 |
Residue: | 568 |
Sequence: | MPSTDLLMLKAFEPYLEILEVYSTKAKNYVNGHCTKYEPWQLIAWSVVWTLLIVWGYEFV
FQPESLWSRFKKKCFKLTRKMPIIGRKIQDKLNKTKDDISKNMSFLKVDKEYVKALPSQG
LSSSAVLEKLKEYSSMDAFWQEGRASGTVYSGEEKLTELLVKAYGDFAWSNPLHPDIFPG
LRKIEAEIVRIACSLFNGGPDSCGCVTSGGTESILMACKAYRDLAFEKGIKTPEIVAPQS
AHAAFNKAASYFGMKIVRVPLTKMMEVDVRAMRRAISRNTAMLVCSTPQFPHGVIDPVPE
VAKLAVKYKIPLHVDACLGGFLIVFMEKAGYPLEHPFDFRVKGVTSISADTHKYGYAPKG
SSLVLYSDKKYRNYQFFVDTDWQGGIYASPTIAGSRPGGISAACWAALMHFGENGYVEAT
KQIIKTARFLKSELENIKGIFVFGNPQLSVIALGSRDFDIYRLSNLMTAKGWNLNQLQFP
PSIHFCITLLHARKRVAIQFLKDIRESVTQIMKNPKAKTTGMGAIYGMAQTTVDRNMVAE
LSSVFLDSLYSTDTVTQGSQMNGSPKPH
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BDBM50018286 |
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n/a |
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Name | BDBM50018286 |
Synonyms: | CHEMBL3290335 |
Type | Small organic molecule |
Emp. Form. | C27H23N7 |
Mol. Mass. | 445.5184 |
SMILES | C[C@@H]1CN(CCN1c1ccc(cn1)C#N)c1nnc(Cc2ccccc2)c2ccc(cc12)C#N |r| |
Structure |
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