| Reaction Details |
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 | Report a problem with these data |
| Target | E3 ubiquitin-protein ligase SMURF1 |
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| Ligand | BDBM50193011 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_1614090 |
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| IC50 | 2.8±n/a nM |
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| Citation |  Abdel-Magid, AF Therapeutic Potential of Smurf-1 Inhibitors for the Treatment of Pulmonary Arterial Hypertension (PAH). ACS Med Chem Lett7:878-880 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| E3 ubiquitin-protein ligase SMURF1 |
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| Name: | E3 ubiquitin-protein ligase SMURF1 |
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| Synonyms: | E3 ubiquitin-protein ligase SMURF1 | HECT-type E3 ubiquitin transferase SMURF1 | KIAA1625 | SMAD ubiquitination regulatory factor 1 | SMAD-specific E3 ubiquitin-protein ligase 1 | SMUF1_HUMAN | SMURF1 | hSMURF1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 86120.64 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_116984 |
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| Residue: | 757 |
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| Sequence: | MSNPGTRRNGSSIKIRLTVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDP
KWNQHYDLYVGKTDSITISVWNHKKIHKKQGAGFLGCVRLLSNAISRLKDTGYQRLDLCK
LNPSDTDAVRGQIVVSLQTRDRIGTGGSVVDCRGLLENEGTVYEDSGPGRPLSCFMEEPA
PYTDSTGAAAGGGNCRFVESPSQDQRLQAQRLRNPDVRGSLQTPQNRPHGHQSPELPEGY
EQRTTVQGQVYFLHTQTGVSTWHDPRIPSPSGTIPGGDAAFLYEFLLQGHTSEPRDLNSV
NCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQLKEPSQPLPLPS
EGSLEDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMR
PKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSS
INPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLV
WILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGI
EAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVR
WFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLP
KAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAVE
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| BDBM50193011 |
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| n/a |
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| Name | BDBM50193011 |
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| Synonyms: | CHEMBL3945602 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H36N4O3 |
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| Mol. Mass. | 440.5783 |
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| SMILES | CC(C)C1CCC(=CC1)c1onc(C(O)=Nc2c(C)n(C)n(C3CCCCC3)c2=O)c1C |c:6| |
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| Structure | 
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