| Reaction Details |
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 | Report a problem with these data |
| Target | P2X purinoceptor 7 |
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| Ligand | BDBM50191064 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1617108 (CHEMBL3859177) |
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| IC50 | 1091±n/a nM |
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| Citation |  Rech, JC; Bhattacharya, A; Branstetter, BJ; Love, CJ; Leenaerts, JE; Cooymans, LP; Eckert, WA; Ao, H; Wang, Q; Chaplan, SR; Wickenden, AD; Lebsack, AD; Breitenbucher, JG The discovery and preclinical characterization of 6-chloro-N-(2-(4,4-difluoropiperidin-1-yl)-2-(2-(trifluoromethyl)pyrimidin-5-yl)ethyl)quinoline-5-carboxamide based P2X7 antagonists. Bioorg Med Chem Lett26:4781-4784 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| P2X purinoceptor 7 |
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| Name: | P2X purinoceptor 7 |
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| Synonyms: | P2RX7_MOUSE | P2rx7 | P2x7 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 68405.16 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_1473824 |
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| Residue: | 595 |
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| Sequence: | MPACCSWNDVLQYETNKVTRIQSTNYGTVKWVLHMIVFSYISFALVSDKLYQRKEPVISS
VHTKVKGIAEVTENVTEGGVTKLGHSIFDTADYTFPLQGNSFFVMTNYVKSEGQVQTLCP
EYPRRGAQCSSDRRCKKGWMDPQSKGIQTGRCVPYDKTRKTCEVSAWCPTEEEKEAPRPA
LLRSAENFTVLIKNNIHFPGHNYTTRNILPTMNGSCTFHKTWDPQCSIFRLGDIFQEAGE
NFTEVAVQGGIMGIEIYWDCNLDSWSHHCRPRYSFRRLDDKNTDESFVPGYNFRYAKYYK
ENNVEKRTLIKAFGIRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLATVCIDLLINTYSS
AFCRSGVYPYCKCCEPCTVNEYYYRKKCESIMEPKPTLKYVSFVDEPHIRMVDQQLLGKS
LQVVKGQEVPRPQMDFSDLSRLSLSLHDSPLTPGQSEEIQLLHEEVAPKSGDSPSWCQCG
NCLPSRLPEQRRALEELCCRRKPGRCITTSKLFHKLVLSRDTLQLLLLYQDPLLVLGEEA
TNSRLRHRAYRCYATWRFGSQDMADFAILPSCCRWRIRKEFPKTEGQYSGFKYPY
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| BDBM50191064 |
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| n/a |
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| Name | BDBM50191064 |
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| Synonyms: | CHEMBL3894220 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H20ClF5N6O |
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| Mol. Mass. | 514.879 |
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| SMILES | Nc1ccc2c(C(=O)NCC(N3CCC(F)(F)CC3)c3cnc(nc3)C(F)(F)F)c(Cl)ccc2n1 |
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| Structure | 
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