| Reaction Details |
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 | Report a problem with these data |
| Target | Smoothened homolog |
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| Ligand | BDBM50196085 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1618171 (CHEMBL3860340) |
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| EC50 | 800±n/a nM |
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| Citation |  Manetti, F; Petricci, E; Gabrielli, A; Mann, A; Faure, H; Gorojankina, T; Brasseur, L; Hoch, L; Ruat, M; Taddei, M Design, synthesis and biological characterization of a new class of osteogenic (1H)-quinolone derivatives. Eur J Med Chem121:747-757 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Smoothened homolog |
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| Name: | Smoothened homolog |
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| Synonyms: | SMO_MOUSE | Smo | Smoh |
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| Type: | PROTEIN |
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| Mol. Mass.: | 87472.73 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_1510377 |
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| Residue: | 793 |
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| Sequence: | MAAGRPVRGPELAPRRLLQLLLLVLLGGPGRGAALSGNVTGPGPHSASGSSRRDVPVTSP
PPPLLSHCGRAAHCEPLRYNVCLGSALPYGATTTLLAGDSDSQEEAHGKLVLWSGLRNAP
RCWAVIQPLLCAVYMPKCENDRVELPSRTLCQATRGPCAIVERERGWPDFLRCTPDHFPE
GCPNEVQNIKFNSSGQCEAPLVRTDNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAA
FGAVTGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCR
ADGTMRFGEPTSSETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTYQPLSGK
TSYFHLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGG
YFLIRGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFN
QAEWERSFRDYVLCQANVTIGLPTKKPIPDCEIKNRPSLLVEKINLFAMFGTGIAMSTWV
WTKATLLIWRRTWCRLTGHSDDEPKRIKKSKMIAKAFSKRRELLQNPGQELSFSMHTVSH
DGPVAGLAFDLNEPSADVSSAWAQHVTKMVARRGAILPQDVSVTPVATPVPPEEQANMWL
VEAEISPELEKRLGRKKKRRKRKKEVCPLRPAPELHHSAPVPATSAVPRLPQLPRQKCLV
AANAWGTGESCRQGAWTLVSNPFCPEPSPHQDPFLPGASAPRVWAQGRLQGLGSIHSRTN
LMEAEILDADSDF
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| BDBM50196085 |
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| n/a |
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| Name | BDBM50196085 |
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| Synonyms: | CHEMBL3941789 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H26N2O5 |
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| Mol. Mass. | 422.4736 |
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| SMILES | CCCCn1c2ccccc2c(O)c(C(=O)Nc2ccc(cc2)C(=O)OCCC)c1=O |
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| Structure | 
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