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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' | ||
| Ligand | BDBM50196675 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1618858 (CHEMBL3861027) | ||
| IC50 | 2.6±n/a nM | ||
| Citation |  Rabal, O; Sánchez-Arias, JA; Cuadrado-Tejedor, M; de Miguel, I; Pérez-González, M; García-Barroso, C; Ugarte, A; Estella-Hermoso de Mendoza, A; Sáez, E; Espelosin, M; Ursua, S; Haizhong, T; Wei, W; Musheng, X; Garcia-Osta, A; Oyarzabal, J Design, Synthesis, and Biological Evaluation of First-in-Class Dual Acting Histone Deacetylases (HDACs) and Phosphodiesterase 5 (PDE5) Inhibitors for the Treatment of Alzheimer's Disease. J Med Chem59:8967-9004 (2016) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' | |||
| Name: | Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' | ||
| Synonyms: | 3',5'-cyclic phosphodiesterase | PDE6C | PDE6C_HUMAN | PDEA2 | Phosphodiesterase 6C | Phosphodiesterase 6C (PDE6C) | ||
| Type: | Protein | ||
| Mol. Mass.: | 99132.02 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P51160 | ||
| Residue: | 858 | ||
| Sequence: |
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| BDBM50196675 | |||
| n/a | |||
| Name | BDBM50196675 | ||
| Synonyms: | CHEMBL3900593 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H27N5O4 | ||
| Mol. Mass. | 425.4809 | ||
| SMILES | CCOc1ccc(CC2CC(C2)C(=O)NO)cc1-c1nc2c(CC)nn(C)c2c(=O)[nH]1 |(44.14,-3.5,;44.14,-5.04,;45.47,-5.81,;45.47,-7.35,;44.14,-8.12,;44.14,-9.66,;45.49,-10.43,;45.49,-11.97,;46.83,-12.74,;47.23,-14.22,;48.71,-13.81,;48.31,-12.33,;50.05,-14.58,;50.06,-16.12,;51.38,-13.8,;52.72,-14.56,;46.81,-9.66,;46.81,-8.12,;48.14,-7.35,;49.47,-8.11,;50.8,-7.34,;52.25,-7.82,;52.73,-9.28,;54.24,-9.6,;53.16,-6.58,;52.25,-5.34,;52.73,-3.87,;50.8,-5.81,;49.47,-5.03,;49.47,-3.49,;48.14,-5.81,)| | ||
| Structure | 
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