| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Excitatory amino acid transporter 1 |
|---|
| Ligand | BDBM50197046 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1619055 (CHEMBL3861224) |
|---|
| IC50 | 2300±n/a nM |
|---|
| Citation |  Hansen, JC; Bjørn-Yoshimoto, WE; Bisballe, N; Nielsen, B; Jensen, AA; Bunch, L ß-Sulfonamido Functionalized Aspartate Analogues as Excitatory Amino Acid Transporter Inhibitors: Distinct Subtype Selectivity Profiles Arising from Subtle Structural Differences. J Med Chem59:8771-8786 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Excitatory amino acid transporter 1 |
|---|
| Name: | Excitatory amino acid transporter 1 |
|---|
| Synonyms: | EAA1_HUMAN | EAAT1 | Excitatory Amino Acid EAAT1 | GLAST | GLAST1 | SLC1A3 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 59577.19 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Excitatory Amino Acid EAAT1 0 HUMAN::P43003 |
|---|
| Residue: | 542 |
|---|
| Sequence: | MTKSNGEEPKMGGRMERFQQGVRKRTLLAKKKVQNITKEDVKSYLFRNAFVLLTVTAVIV
GTILGFTLRPYRMSYREVKYFSFPGELLMRMLQMLVLPLIISSLVTGMAALDSKASGKMG
MRAVVYYMTTTIIAVVIGIIIVIIIHPGKGTKENMHREGKIVRVTAADAFLDLIRNMFPP
NLVEACFKQFKTNYEKRSFKVPIQANETLVGAVINNVSEAMETLTRITEELVPVPGSVNG
VNALGLVVFSMCFGFVIGNMKEQGQALREFFDSLNEAIMRLVAVIMWYAPVGILFLIAGK
IVEMEDMGVIGGQLAMYTVTVIVGLLIHAVIVLPLLYFLVTRKNPWVFIGGLLQALITAL
GTSSSSATLPITFKCLEENNGVDKRVTRFVLPVGATINMDGTALYEALAAIFIAQVNNFE
LNFGQIITISITATAASIGAAGIPQAGLVTMVIVLTSVGLPTDDITLIIAVDWFLDRLRT
TTNVLGDSLGAGIVEHLSRHELKNRDVEMGNSVIEENEMKKPYQLIAQDNETEKPIDSET
KM
|
|
|
|---|
| BDBM50197046 |
|---|
| n/a |
|---|
| Name | BDBM50197046 |
|---|
| Synonyms: | CHEMBL3939524 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H16N2O6S |
|---|
| Mol. Mass. | 364.373 |
|---|
| SMILES | N[C@@H](C(NS(=O)(=O)c1ccc(cc1)-c1ccccc1)C(O)=O)C(O)=O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
