| Reaction Details |
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 | Report a problem with these data |
| Target | Excitatory amino acid transporter 2 |
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| Ligand | BDBM50197046 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1619056 (CHEMBL3861225) |
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| IC50 | 501±n/a nM |
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| Citation |  Hansen, JC; Bjørn-Yoshimoto, WE; Bisballe, N; Nielsen, B; Jensen, AA; Bunch, L ß-Sulfonamido Functionalized Aspartate Analogues as Excitatory Amino Acid Transporter Inhibitors: Distinct Subtype Selectivity Profiles Arising from Subtle Structural Differences. J Med Chem59:8771-8786 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Excitatory amino acid transporter 2 |
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| Name: | Excitatory amino acid transporter 2 |
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| Synonyms: | EAA2_HUMAN | EAAT2 | GLT1 | Glutamate/aspartate transporter II | SLC1A2 | Sodium-dependent glutamate/aspartate transporter 2 | Solute carrier family 1 member 2 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 62103.57 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Excitatory Amino Acid EAAT2 0 0::P43004 |
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| Residue: | 574 |
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| Sequence: | MASTEGANNMPKQVEVRMHDSHLGSEEPKHRHLGLRLCDKLGKNLLLTLTVFGVILGAVC
GGLLRLASPIHPDVVMLIAFPGDILMRMLKMLILPLIISSLITGLSGLDAKASGRLGTRA
MVYYMSTTIIAAVLGVILVLAIHPGNPKLKKQLGPGKKNDEVSSLDAFLDLIRNLFPENL
VQACFQQIQTVTKKVLVAPPPDEEANATSAVVSLLNETVTEVPEETKMVIKKGLEFKDGM
NVLGLIGFFIAFGIAMGKMGDQAKLMVDFFNILNEIVMKLVIMIMWYSPLGIACLICGKI
IAIKDLEVVARQLGMYMVTVIIGLIIHGGIFLPLIYFVVTRKNPFSFFAGIFQAWITALG
TASSAGTLPVTFRCLEENLGIDKRVTRFVLPVGATINMDGTALYEAVAAIFIAQMNGVVL
DGGQIVTVSLTATLASVGAASIPSAGLVTMLLILTAVGLPTEDISLLVAVDWLLDRMRTS
VNVVGDSFGAGIVYHLSKSELDTIDSQHRVHEDIEMTKTQSIYDDMKNHRESNSNQCVYA
AHNSVIVDECKVTLAANGKSADCSVEEEPWKREK
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| BDBM50197046 |
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| n/a |
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| Name | BDBM50197046 |
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| Synonyms: | CHEMBL3939524 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H16N2O6S |
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| Mol. Mass. | 364.373 |
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| SMILES | N[C@@H](C(NS(=O)(=O)c1ccc(cc1)-c1ccccc1)C(O)=O)C(O)=O |r| |
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| Structure | 
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