Reaction Details |
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Target | Excitatory amino acid transporter 2 |
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Ligand | BDBM50197054 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1619056 (CHEMBL3861225) |
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IC50 | 2399±n/a nM |
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Citation | Hansen, JC; Bjørn-Yoshimoto, WE; Bisballe, N; Nielsen, B; Jensen, AA; Bunch, L ß-Sulfonamido Functionalized Aspartate Analogues as Excitatory Amino Acid Transporter Inhibitors: Distinct Subtype Selectivity Profiles Arising from Subtle Structural Differences. J Med Chem59:8771-8786 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Excitatory amino acid transporter 2 |
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Name: | Excitatory amino acid transporter 2 |
Synonyms: | EAA2_HUMAN | EAAT2 | GLT1 | Glutamate/aspartate transporter II | SLC1A2 | Sodium-dependent glutamate/aspartate transporter 2 | Solute carrier family 1 member 2 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 62103.57 |
Organism: | Homo sapiens (Human) |
Description: | Excitatory Amino Acid EAAT2 0 0::P43004 |
Residue: | 574 |
Sequence: | MASTEGANNMPKQVEVRMHDSHLGSEEPKHRHLGLRLCDKLGKNLLLTLTVFGVILGAVC
GGLLRLASPIHPDVVMLIAFPGDILMRMLKMLILPLIISSLITGLSGLDAKASGRLGTRA
MVYYMSTTIIAAVLGVILVLAIHPGNPKLKKQLGPGKKNDEVSSLDAFLDLIRNLFPENL
VQACFQQIQTVTKKVLVAPPPDEEANATSAVVSLLNETVTEVPEETKMVIKKGLEFKDGM
NVLGLIGFFIAFGIAMGKMGDQAKLMVDFFNILNEIVMKLVIMIMWYSPLGIACLICGKI
IAIKDLEVVARQLGMYMVTVIIGLIIHGGIFLPLIYFVVTRKNPFSFFAGIFQAWITALG
TASSAGTLPVTFRCLEENLGIDKRVTRFVLPVGATINMDGTALYEAVAAIFIAQMNGVVL
DGGQIVTVSLTATLASVGAASIPSAGLVTMLLILTAVGLPTEDISLLVAVDWLLDRMRTS
VNVVGDSFGAGIVYHLSKSELDTIDSQHRVHEDIEMTKTQSIYDDMKNHRESNSNQCVYA
AHNSVIVDECKVTLAANGKSADCSVEEEPWKREK
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BDBM50197054 |
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n/a |
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Name | BDBM50197054 |
Synonyms: | CHEMBL3937517 |
Type | Small organic molecule |
Emp. Form. | C10H12N2O6S |
Mol. Mass. | 288.277 |
SMILES | N[C@@H]([C@H](NS(=O)(=O)c1ccccc1)C(O)=O)C(O)=O |r| |
Structure |
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