| Reaction Details |
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 | Report a problem with these data |
| Target | Tumor necrosis factor receptor superfamily member 16 |
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| Ligand | BDBM50029495 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1619564 (CHEMBL3861733) |
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| IC50 | 110000±n/a nM |
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| Citation |  Norman, BH; McDermott, JS Targeting the Nerve Growth Factor (NGF) Pathway in Drug Discovery. Potential Applications to New Therapies for Chronic Pain. J Med Chem60:66-88 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tumor necrosis factor receptor superfamily member 16 |
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| Name: | Tumor necrosis factor receptor superfamily member 16 |
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| Synonyms: | CD_antigen=CD271 | Gp80-LNGFR | Low affinity neurotrophin receptor p75NTR | Low-affinity nerve growth factor receptor | NGF receptor | NGFR | TNFRSF16 | TNR16_HUMAN | Tumor necrosis factor receptor superfamily member 16 | p75 ICD |
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| Type: | PROTEIN |
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| Mol. Mass.: | 45159.83 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_346884 |
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| Residue: | 427 |
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| Sequence: | MGAGATGRAMDGPRLLLLLLLGVSLGGAKEACPTGLYTHSGECCKACNLGEGVAQPCGAN
QTVCEPCLDSVTFSDVVSATEPCKPCTECVGLQSMSAPCVEADDAVCRCAYGYYQDETTG
RCEACRVCEAGSGLVFSCQDKQNTVCEECPDGTYSDEANHVDPCLPCTVCEDTERQLREC
TRWADAECEEIPGRWITRSTPPEGSDSTAPSTQEPEAPPEQDLIASTVAGVVTTVMGSSQ
PVVTRGTTDNLIPVYCSILAAVVVGLVAYIAFKRWNSCKQNKQGANSRPVNQTPPPEGEK
LHSDSGISVDSQSLHDQQPHTQTASGQALKGDGGLYSSLPPAKREEVEKLLNGSAGDTWR
HLAGELGYQPEHIDSFTHEACPVRALLASWATQDSATLDALLAALRRIQRADLVESLCSE
STATSPV
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| BDBM50029495 |
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| n/a |
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| Name | BDBM50029495 |
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| Synonyms: | 7-Benzoylamino-4-methyl-9-oxo-4,9-dihydro-pyrazolo[5,1-b]quinazoline-2-carboxylic acid | CHEMBL137953 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H14N4O4 |
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| Mol. Mass. | 362.3389 |
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| SMILES | Cn1c2cc(nn2c(=O)c2cc(NC(=O)c3ccccc3)ccc12)C(O)=O |
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| Structure | 
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