| Reaction Details |
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 | Report a problem with these data |
| Target | Tumor necrosis factor receptor superfamily member 16 |
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| Ligand | BDBM50111443 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1619564 (CHEMBL3861733) |
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| IC50 | >300000±n/a nM |
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| Citation |  Norman, BH; McDermott, JS Targeting the Nerve Growth Factor (NGF) Pathway in Drug Discovery. Potential Applications to New Therapies for Chronic Pain. J Med Chem60:66-88 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tumor necrosis factor receptor superfamily member 16 |
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| Name: | Tumor necrosis factor receptor superfamily member 16 |
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| Synonyms: | CD_antigen=CD271 | Gp80-LNGFR | Low affinity neurotrophin receptor p75NTR | Low-affinity nerve growth factor receptor | NGF receptor | NGFR | TNFRSF16 | TNR16_HUMAN | Tumor necrosis factor receptor superfamily member 16 | p75 ICD |
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| Type: | PROTEIN |
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| Mol. Mass.: | 45159.83 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_346884 |
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| Residue: | 427 |
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| Sequence: | MGAGATGRAMDGPRLLLLLLLGVSLGGAKEACPTGLYTHSGECCKACNLGEGVAQPCGAN
QTVCEPCLDSVTFSDVVSATEPCKPCTECVGLQSMSAPCVEADDAVCRCAYGYYQDETTG
RCEACRVCEAGSGLVFSCQDKQNTVCEECPDGTYSDEANHVDPCLPCTVCEDTERQLREC
TRWADAECEEIPGRWITRSTPPEGSDSTAPSTQEPEAPPEQDLIASTVAGVVTTVMGSSQ
PVVTRGTTDNLIPVYCSILAAVVVGLVAYIAFKRWNSCKQNKQGANSRPVNQTPPPEGEK
LHSDSGISVDSQSLHDQQPHTQTASGQALKGDGGLYSSLPPAKREEVEKLLNGSAGDTWR
HLAGELGYQPEHIDSFTHEACPVRALLASWATQDSATLDALLAALRRIQRADLVESLCSE
STATSPV
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| BDBM50111443 |
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| n/a |
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| Name | BDBM50111443 |
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| Synonyms: | 2-(2-Hydroxy-ethylamino)-5-nitro-benzo[de]isoquinoline-1,3-dione(ALE-0540) | CHEMBL440470 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H11N3O5 |
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| Mol. Mass. | 301.2542 |
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| SMILES | OCCNN1C(=O)c2cccc3cc(cc(C1=O)c23)[N+]([O-])=O |
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| Structure | 
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