| Reaction Details |
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 | Report a problem with these data |
| Target | Sigma non-opioid intracellular receptor 1 |
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| Ligand | BDBM50061885 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1621710 (CHEMBL3863993) |
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| Ki | 2.4±n/a nM |
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| Citation |  Cao, J; Slack, RD; Bakare, OM; Burzynski, C; Rais, R; Slusher, BS; Kopajtic, T; Bonifazi, A; Ellenberger, MP; Yano, H; He, Y; Bi, GH; Xi, ZX; Loland, CJ; Newman, AH Novel and High Affinity 2-[(Diphenylmethyl)sulfinyl]acetamide (Modafinil) Analogues as Atypical Dopamine Transporter Inhibitors. J Med Chem59:10676-10691 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sigma non-opioid intracellular receptor 1 |
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| Name: | Sigma non-opioid intracellular receptor 1 |
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| Synonyms: | OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein |
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| Type: | Protein |
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| Mol. Mass.: | 25307.17 |
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| Organism: | Cavia porcellus (Guinea pig) |
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| Description: | Q60492 |
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| Residue: | 223 |
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| Sequence: | MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSK
LIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRY
WAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPS
TLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
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| BDBM50061885 |
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| n/a |
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| Name | BDBM50061885 |
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| Synonyms: | 3-[Bis-(4-fluoro-phenyl)-methoxy]-8-butyl-8-aza-bicyclo[3.2.1]octane | CHEMBL11493 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H29F2NO |
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| Mol. Mass. | 385.49 |
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| SMILES | CCCCN1C2CCC1CC(C2)OC(c1ccc(F)cc1)c1ccc(F)cc1 |THB:12:10:4:6.7| |
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| Structure | 
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