Reaction Details |
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Target | Caspase-5 |
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Ligand | BDBM50200552 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1622627 (CHEMBL3864979) |
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IC50 | 210±n/a nM |
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Citation | Kent, CR; Bryja, M; Gustafson, HA; Kawarski, MY; Lenti, G; Pierce, EN; Knopp, RC; Ceja, V; Pati, B; Walters, DE; Karver, CE Variation of the aryl substituent on the piperazine ring within the 4-(piperazin-1-yl)-2,6-di(pyrrolidin-1-yl)pyrimidine scaffold unveils potent, non-competitive inhibitors of the inflammatory caspases. Bioorg Med Chem Lett26:5476-5480 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Caspase-5 |
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Name: | Caspase-5 |
Synonyms: | CASP-5 | CASP5 | CASP5_HUMAN | Caspase 5 | Caspase-5 subunit p10 | Caspase-5 subunit p20 | ICE(rel)-III | ICH-3 protease | ICH3 | Protease ICH-3 | Protease TY | TY protease |
Type: | Enzyme |
Mol. Mass.: | 49760.80 |
Organism: | Homo sapiens (Human) |
Description: | P51878 |
Residue: | 434 |
Sequence: | MAEDSGKKKRRKNFEAMFKGILQSGLDNFVINHMLKNNVAGQTSIQTLVPNTDQKSTSVK
KDNHKKKTVKMLEYLGKDVLHGVFNYLAKHDVLTLKEEEKKKYYDTKIEDKALILVDSLR
KNRVAHQMFTQTLLNMDQKITSVKPLLQIEAGPPESAESTNILKLCPREEFLRLCKKNHD
EIYPIKKREDRRRLALIICNTKFDHLPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARD
MESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNC
LSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVCKIHEEKDFIAF
CSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSFEVPQAKAQMPTIE
RATLTRDFYLFPGN
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BDBM50200552 |
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n/a |
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Name | BDBM50200552 |
Synonyms: | CHEMBL3898411 |
Type | Small organic molecule |
Emp. Form. | C25H30F6N6 |
Mol. Mass. | 528.5363 |
SMILES | FC(F)(F)c1cc(CN2CCN(CC2)c2cc(nc(n2)N2CCCC2)N2CCCC2)cc(c1)C(F)(F)F |
Structure |
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