| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydroorotate dehydrogenase (quinone), mitochondrial |
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| Ligand | BDBM85507 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1623169 (CHEMBL3865521) |
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| IC50 | 17000±n/a nM |
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| Citation |  Lewis, TA; Sykes, DB; Law, JM; Muņoz, B; Rustiguel, JK; Nonato, MC; Scadden, DT; Schreiber, SL Development of ML390: A Human DHODH Inhibitor That Induces Differentiation in Acute Myeloid Leukemia. ACS Med Chem Lett7:1112-1117 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydroorotate dehydrogenase (quinone), mitochondrial |
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| Name: | Dihydroorotate dehydrogenase (quinone), mitochondrial |
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| Synonyms: | DHODH | DHOdehase | Dihydroorotate dehydrogenase | Dihydroorotate dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial | Dihydroorotate oxidase | Dihydroorotate oxidase (DHODH) | PYRD_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 42881.33 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q02127 |
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| Residue: | 395 |
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| Sequence: | MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVR
FTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSV
TPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVN
LGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQER
DGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSET
GGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTF
WGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR
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| BDBM85507 |
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| n/a |
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| Name | BDBM85507 |
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| Synonyms: | CAS_4394-00-7 | NSC_4488 | Niflumic acid | Niflumic acid (Hit 16) | US10278929, Niflumic acid | US11337935, Compound Niflumic-acid | US20240002326, Compound Niflumic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C13H9F3N2O2 |
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| Mol. Mass. | 282.218 |
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| SMILES | OC(=O)c1cccnc1Nc1cccc(c1)C(F)(F)F |
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| Structure | 
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