Reaction Details |
| Report a problem with these data |
Target | DNA gyrase subunit B |
---|
Ligand | BDBM50202010 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEBML_1623809 |
---|
IC50 | 43900±n/a nM |
---|
Citation | Jeankumar, VU; Reshma, RS; Vats, R; Janupally, R; Saxena, S; Yogeeswari, P; Sriram, D Engineering another class of anti-tubercular lead: Hit to lead optimization of an intriguing class of gyrase ATPase inhibitors. Eur J Med Chem122:216-231 (2016) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
DNA gyrase subunit B |
---|
Name: | DNA gyrase subunit B |
Synonyms: | GYRB_MYCSM | gyrB |
Type: | PROTEIN |
Mol. Mass.: | 74505.25 |
Organism: | Mycobacterium smegmatis |
Description: | ChEMBL_107961 |
Residue: | 675 |
Sequence: | MAAQKNNAPKEYGADSITILEGLEAVRKRPGMYIGSTGERGLHHLIWEVVDNAVDEAMAG
FATRVDVKIHADGSVEVRDDGRGIPVEMHATGMPTIDVVMTQLHAGGKFDGETYAVSGGL
HGVGVSVVNALSTRLEATVLRDGYEWFQYYDRSVPGKLKQGGETKETGTTIRFWADPEIF
ETTDYNFETVARRLQEMAFLNKGLTIELTDERVTAEEVVDDVVKDTAEAPKTADEKAAEA
TGPSKVKHRVFHYPGGLVDYVKHINRTKTPIQQSIIDFDGKGPGHEVEIAMQWNAGYSES
VHTFANTINTHEGGTHEEGFRAALTSVVNRYAKDKKLLKDKDPNLTGDDIREGLAAVISV
KVAEPQFEGQTKTKLGNTEVKSFVQKICNEQLQHWFEANPAEAKTVVNKAVSSAQARIAA
RKARELVRRKSATDIGGLPGKLADCRSTDPSKSELYVVEGDSAGGSAKSGRDSMFQAILP
LRGKIINVEKARIDRVLKNTEVQSIITALGTGIHDEFDISKLRYHKIVLMADADVDGQHI
STLLLTLLFRFMKPLVENGHIFLAQPPLYKLKWQRSEPEFAYSDRERDGLLEAGRAAGKK
INVDDGIQRYKGLGEMDAKELWETTMDPSVRVLRQVTLDDAAAADELFSILMGEDVEARR
SFITRNAKDVRFLDV
|
|
|
BDBM50202010 |
---|
n/a |
---|
Name | BDBM50202010 |
Synonyms: | CHEMBL3952721 |
Type | Small organic molecule |
Emp. Form. | C17H21ClN4O |
Mol. Mass. | 332.828 |
SMILES | CC(C)NC(=O)N1CCN(CC1)c1ccnc2cc(Cl)ccc12 |
Structure |
|