| Reaction Details |
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 | Report a problem with these data |
| Target | DNA gyrase subunit B |
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| Ligand | BDBM50202012 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_1623809 |
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| IC50 | 13800±n/a nM |
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| Citation |  Jeankumar, VU; Reshma, RS; Vats, R; Janupally, R; Saxena, S; Yogeeswari, P; Sriram, D Engineering another class of anti-tubercular lead: Hit to lead optimization of an intriguing class of gyrase ATPase inhibitors. Eur J Med Chem122:216-231 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| DNA gyrase subunit B |
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| Name: | DNA gyrase subunit B |
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| Synonyms: | GYRB_MYCSM | gyrB |
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| Type: | PROTEIN |
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| Mol. Mass.: | 74505.25 |
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| Organism: | Mycobacterium smegmatis |
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| Description: | ChEMBL_107961 |
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| Residue: | 675 |
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| Sequence: | MAAQKNNAPKEYGADSITILEGLEAVRKRPGMYIGSTGERGLHHLIWEVVDNAVDEAMAG
FATRVDVKIHADGSVEVRDDGRGIPVEMHATGMPTIDVVMTQLHAGGKFDGETYAVSGGL
HGVGVSVVNALSTRLEATVLRDGYEWFQYYDRSVPGKLKQGGETKETGTTIRFWADPEIF
ETTDYNFETVARRLQEMAFLNKGLTIELTDERVTAEEVVDDVVKDTAEAPKTADEKAAEA
TGPSKVKHRVFHYPGGLVDYVKHINRTKTPIQQSIIDFDGKGPGHEVEIAMQWNAGYSES
VHTFANTINTHEGGTHEEGFRAALTSVVNRYAKDKKLLKDKDPNLTGDDIREGLAAVISV
KVAEPQFEGQTKTKLGNTEVKSFVQKICNEQLQHWFEANPAEAKTVVNKAVSSAQARIAA
RKARELVRRKSATDIGGLPGKLADCRSTDPSKSELYVVEGDSAGGSAKSGRDSMFQAILP
LRGKIINVEKARIDRVLKNTEVQSIITALGTGIHDEFDISKLRYHKIVLMADADVDGQHI
STLLLTLLFRFMKPLVENGHIFLAQPPLYKLKWQRSEPEFAYSDRERDGLLEAGRAAGKK
INVDDGIQRYKGLGEMDAKELWETTMDPSVRVLRQVTLDDAAAADELFSILMGEDVEARR
SFITRNAKDVRFLDV
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| BDBM50202012 |
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| n/a |
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| Name | BDBM50202012 |
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| Synonyms: | CHEMBL3967891 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H21ClN4S |
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| Mol. Mass. | 396.936 |
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| SMILES | Cc1ccc(NC(=S)N2CCN(CC2)c2ccnc3cc(Cl)ccc23)cc1 |
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| Structure | 
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