| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-A2/Cyclin-dependent kinase 1 |
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| Ligand | BDBM50202432 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1624047 (CHEMBL3866459) |
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| IC50 | 2.8±n/a nM |
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| Citation |  Ibrahim, HS; Abou-Seri, SM; Abdel-Aziz, HA 3-Hydrazinoindolin-2-one derivatives: Chemical classification and investigation of their targets as anticancer agents. Eur J Med Chem122:366-381 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclin-A2/Cyclin-dependent kinase 1 |
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| Name: | Cyclin-A2/Cyclin-dependent kinase 1 |
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| Synonyms: | CDK1/Cyclin A | Cyclin-Dependent Kinase 1 (CDK1) |
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| Type: | Protein Complex |
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| Mol. Mass.: | n/a |
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| Description: | CDK1 was expressed in a baculovirus expression system and was partially purified. Cyclin A was purified separately and mixed with CDK1 before assays. |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Cyclin-dependent kinase 1 |
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| Synonyms: | CDC2 | CDC28A | CDK1 | CDK1_HUMAN | CDKN1 | Cell division control protein 2 homolog | Cell division protein kinase 1 | Cyclin-dependent kinase 1 (CDK1) | P34CDC2 | p34 protein kinase |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 34101.08 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P06493 |
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| Residue: | 297 |
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| Sequence: | MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH
PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH
SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR
YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT
FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM
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| Component 2 |
| Name: | Cyclin-A2 |
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| Synonyms: | CCN1 | CCNA | CCNA1 | CCNA2 | CCNA2_HUMAN | Cyclin A | Cyclin-A |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 48550.19 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P20248 |
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| Residue: | 432 |
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| Sequence: | MLGNSAPGPATREAGSALLALQQTALQEDQENINPEKAAPVQQPRTRAALAVLKSGNPRG
LAQQQRPKTRRVAPLKDLPVNDEHVTVPPWKANSKQPAFTIHVDEAEKEAQKKPAESQKI
EREDALAFNSAISLPGPRKPLVPLDYPMDGSFESPHTMDMSIILEDEKPVSVNEVPDYHE
DIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYID
RFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLK
VLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAF
HLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHG
VSLLNPPETLNL
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| BDBM50202432 |
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| n/a |
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| Name | BDBM50202432 |
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| Synonyms: | CHEMBL410883 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H13N5O4S |
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| Mol. Mass. | 359.36 |
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| SMILES | NC(=O)c1ccc2NC(=O)\C(=N/Nc3ccc(cc3)S(N)(=O)=O)c2c1 |
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| Structure | 
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