| Reaction Details |
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 | Report a problem with these data |
| Target | Retinoic acid receptor gamma |
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| Ligand | BDBM50203502 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1625735 (CHEMBL3868204) |
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| IC50 | 7700±n/a nM |
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| Citation |  Ouvry, G; Bouix-Peter, C; Ciesielski, F; Chantalat, L; Christin, O; Comino, C; Duvert, D; Feret, C; Harris, CS; Lamy, L; Luzy, AP; Musicki, B; Orfila, D; Pascau, J; Parnet, V; Perrin, A; Pierre, R; Polge, G; Raffin, C; Rival, Y; Taquet, N; Thoreau, E; Hennequin, LF Discovery of phenoxyindazoles and phenylthioindazoles as ROR¿ inverse agonists. Bioorg Med Chem Lett26:5802-5808 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Retinoic acid receptor gamma |
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| Name: | Retinoic acid receptor gamma |
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| Synonyms: | NR1B3 | Nuclear receptor subfamily 1 group B member 3 | RAR-gamma | RARG | RARG_HUMAN | Retinoic acid receptor RXR-alpha/gamma | Retinoic acid receptor gamma | Retinoid receptor |
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| Type: | PROTEIN |
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| Mol. Mass.: | 50345.43 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1458016 |
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| Residue: | 454 |
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| Sequence: | MATNKERLFAAGALGPGSGYPGAGFPFAFPGALRGSPPFEMLSPSFRGLGQPDLPKEMAS
LSVETQSTSSEEMVPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQK
NMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKEVKEEGSPDSY
ELSPQLEELITKVSKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDKFSELATKCIIK
IVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMH
NAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEA
LRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREMLENPE
MFEDDSSQPGPHPNASSEDEVPGGQGKGGLKSPA
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| BDBM50203502 |
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| n/a |
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| Name | BDBM50203502 |
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| Synonyms: | CHEMBL3940207 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H22Cl2N4O3S |
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| Mol. Mass. | 541.449 |
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| SMILES | CN1CCN(CC1)C(=O)c1ccc2n(nc(Sc3c(Cl)cccc3Cl)c2c1)-c1ccc(cc1)C(O)=O |
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| Structure | 
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