Reaction Details |
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Target | Neutrophil collagenase |
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Ligand | BDBM50203962 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1625933 (CHEMBL3868402) |
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IC50 | 19±n/a nM |
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Citation | Nara, H; Sato, K; Kaieda, A; Oki, H; Kuno, H; Santou, T; Kanzaki, N; Terauchi, J; Uchikawa, O; Kori, M Design, synthesis, and biological activity of novel, potent, and highly selective fused pyrimidine-2-carboxamide-4-one-based matrix metalloproteinase (MMP)-13 zinc-binding inhibitors. Bioorg Med Chem24:6149-6165 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Neutrophil collagenase |
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Name: | Neutrophil collagenase |
Synonyms: | CLG1 | MMP-8 | MMP8 | MMP8_HUMAN | Matrix metalloproteinase-8 | Neutrophil collagenase precursor | PMNL collagenase | PMNL-CL |
Type: | Enzyme |
Mol. Mass.: | 53413.48 |
Organism: | Homo sapiens (Human) |
Description: | P22894 |
Residue: | 467 |
Sequence: | MFSLKTLPFLLLLHVQISKAFPVSSKEKNTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIV
EKLKEMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNY
TPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGIL
AHAFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYA
FRETSNYSLPQDDIDGIQAIYGLSSNPIQPTGPSTPKPCDPSLTFDAITTLRGEILFFKD
RYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWALSGYDILQG
YPKDISNYGFPSSVQAIDAAVFYRSKTYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGI
ESKVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNCRYG
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BDBM50203962 |
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n/a |
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Name | BDBM50203962 |
Synonyms: | CHEMBL3917494 |
Type | Small organic molecule |
Emp. Form. | C28H29N5O6S |
Mol. Mass. | 563.625 |
SMILES | CC(C)C(CS(=O)(=O)c1ccc(cc1)-c1cccc(CNC(=O)c2nc3ccccc3c(=O)[nH]2)c1)N(O)C(N)=O |
Structure |
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