Reaction Details |
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Target | Polyunsaturated fatty acid lipoxygenase ALOX15 |
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Ligand | BDBM50206314 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1628730 (CHEMBL3871356) |
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IC50 | 20600±n/a nM |
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Citation | Eleftheriadis, N; Poelman, H; Leus, NGJ; Honrath, B; Neochoritis, CG; Dolga, A; Dömling, A; Dekker, FJ Design of a novel thiophene inhibitor of 15-lipoxygenase-1 with both anti-inflammatory and neuroprotective properties. Eur J Med Chem122:786-801 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Polyunsaturated fatty acid lipoxygenase ALOX15 |
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Name: | Polyunsaturated fatty acid lipoxygenase ALOX15 |
Synonyms: | 15-Lipoxygenase-1 (15-LOX-1) | ALOX15 | Arachidonate 15-lipoxygenase | Arachidonate 15-lipoxygenase-1 | LOG15 | LOX15_HUMAN | Reticulocyte 15-lipoxygenase-1 | Sphingosine 1-phosphate receptor 1 (S1P1) |
Type: | Protein |
Mol. Mass.: | 74804.05 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 662 |
Sequence: | MGLYRIRVSTGASLYAGSNNQVQLWLVGQHGEAALGKRLWPARGKETELKVEVPEYLGPL
LFVKLRKRHLLKDDAWFCNWISVQGPGAGDEVRFPCYRWVEGNGVLSLPEGTGRTVGEDP
QGLFQKHREEELEERRKLYRWGNWKDGLILNMAGAKLYDLPVDERFLEDKRVDFEVSLAK
GLADLAIKDSLNVLTCWKDLDDFNRIFWCGQSKLAERVRDSWKEDALFGYQFLNGANPVV
LRRSAHLPARLVFPPGMEELQAQLEKELEGGTLFEADFSLLDGIKANVILCSQQHLAAPL
VMLKLQPDGKLLPMVIQLQLPRTGSPPPPLFLPTDPPMAWLLAKCWVRSSDFQLHELQSH
LLRGHLMAEVIVVATMRCLPSIHPIFKLIIPHLRYTLEINVRARTGLVSDMGIFDQIMST
GGGGHVQLLKQAGAFLTYSSFCPPDDLADRGLLGVKSSFYAQDALRLWEIIYRYVEGIVS
LHYKTDVAVKDDPELQTWCREITEIGLQGAQDRGFPVSLQARDQVCHFVTMCIFTCTGQH
ASVHLGQLDWYSWVPNAPCTMRLPPPTTKDATLETVMATLPNFHQASLQMSITWQLGRRQ
PVMVAVGQHEEEYFSGPEPKAVLKKFREELAALDKEIEIRNAKLDMPYEYLRPSVVENSV
AI
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BDBM50206314 |
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n/a |
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Name | BDBM50206314 |
Synonyms: | CHEMBL2131121 |
Type | Small organic molecule |
Emp. Form. | C14H14N2OS |
Mol. Mass. | 258.339 |
SMILES | Nc1sc(cc1C(=O)NCC=C)-c1ccccc1 |
Structure |
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