| Reaction Details |
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 | Report a problem with these data |
| Target | Steroid 17-alpha-hydroxylase/17,20 lyase |
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| Ligand | BDBM50206959 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1629491 (CHEMBL3872117) |
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| IC50 | >10000±n/a nM |
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| Citation |  Whitehead, BR; Lo, MM; Ali, A; Park, MK; Hoyt, SB; Xiong, Y; Cai, J; Carswell, E; Cooke, A; MacLean, J; Ratcliffe, P; Robinson, J; Bennett, DJ; Clemas, JA; Wisniewski, T; Struthers, M; Cully, D; MacNeil, DJ Imidazopyridyl compounds as aldosterone synthase inhibitors. Bioorg Med Chem Lett27:143-146 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Steroid 17-alpha-hydroxylase/17,20 lyase |
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| Name: | Steroid 17-alpha-hydroxylase/17,20 lyase |
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| Synonyms: | CP17A_HUMAN | CYP17 | CYP17A1 | CYPXVII | Cytochrome P450 17A1 | Cytochrome P450 C17 (CYP17 ) | Cytochrome P450 C17 (CYP17) | Cytochrome P450 CYP17 | Cytochrome P450-C17 | Cytochrome P450-C17 (CYP17) | P450-C17 | S17AH | Steroid 17-alpha-Monooxygenase (CYP17) | Steroid 17-alpha-hydroxylase/17,20 lyase | Steroid 17-alpha-monooxygenase | cytochrome P450 monooxygenase 17 alpha hydroxylase/17,20-lyase (CYP17) |
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| Type: | Enzyme |
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| Mol. Mass.: | 57382.42 |
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| Organism: | Homo sapiens (Human) |
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| Description: | E.coli expressing human CYP17 |
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| Residue: | 508 |
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| Sequence: | MWELVALLLLTLAYLFWPKRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKY
GPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAH
WQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVIS
LICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRN
DLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIF
GAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREV
LRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNP
AGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIP
KVVFLIDSFKVKIKVRQAWREAQAEGST
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| BDBM50206959 |
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| n/a |
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| Name | BDBM50206959 |
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| Synonyms: | CHEMBL3924257 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H13F2N3 |
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| Mol. Mass. | 285.2913 |
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| SMILES | Cc1c(F)cncc1-c1nc2ccc(F)cn2c1C1CC1 |
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| Structure | 
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