Reaction Details |
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Target | Cytochrome P450 11B2, mitochondrial |
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Ligand | BDBM50206963 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1629493 (CHEMBL3872119) |
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IC50 | 0.600000±n/a nM |
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Citation | Whitehead, BR; Lo, MM; Ali, A; Park, MK; Hoyt, SB; Xiong, Y; Cai, J; Carswell, E; Cooke, A; MacLean, J; Ratcliffe, P; Robinson, J; Bennett, DJ; Clemas, JA; Wisniewski, T; Struthers, M; Cully, D; MacNeil, DJ Imidazopyridyl compounds as aldosterone synthase inhibitors. Bioorg Med Chem Lett27:143-146 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cytochrome P450 11B2, mitochondrial |
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Name: | Cytochrome P450 11B2, mitochondrial |
Synonyms: | Aldosterone Synthase (CYP11B2) | Aldosterone synthase | Aldosterone-synthesizing enzyme | C11B2_HUMAN | CYP11B2 | CYPXIB2 | Cytochrome P450 11B2 | Cytochrome P450 11B2 (CYP11B2) | Cytochrome P450 11B2, mitochondrial | P-450Aldo | P-450C18 | Steroid 18-hydroxylase |
Type: | Protein |
Mol. Mass.: | 57582.15 |
Organism: | Homo sapiens (Human) |
Description: | P19099 |
Residue: | 503 |
Sequence: | MALRAKAEVCVAAPWLSLQRARALGTRAARAPRTVLPFEAMPQHPGNRWLRLLQIWREQG
YEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYR
QHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNA
RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM
PRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELS
LEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATT
ELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRP
ERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQED
IKMVYSFILRPGTSPLLTFRAIN
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BDBM50206963 |
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n/a |
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Name | BDBM50206963 |
Synonyms: | CHEMBL3948337 | US9518055, Example 41 |
Type | Small organic molecule |
Emp. Form. | C19H14FN3 |
Mol. Mass. | 303.333 |
SMILES | Fc1ccc2nc(c(C3CC3)n2c1)-c1cncc2ccccc12 |
Structure |
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