Reaction Details | |||
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Target | 5-hydroxytryptamine receptor 1A | ||
Ligand | BDBM50207152 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1630051 (CHEMBL3872757) | ||
Ki | 1.4±n/a nM | ||
Citation | Chen, XW; Sun, YY; Fu, L; Li, JQ Synthesis and pharmacological characterization of novel N-(trans-4-(2-(4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)ethyl)cyclohexyl)amides as potential multireceptor atypical antipsychotics. Eur J Med Chem123:332-353 (2016) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
5-hydroxytryptamine receptor 1A | |||
Name: | 5-hydroxytryptamine receptor 1A | ||
Synonyms: | 5-HT-1A | 5-HT1A | 5-hydroxytryptamine receptor 1A (5-HT-1A) | 5HT1A_HUMAN | ADRB2RL1 | ADRBRL1 | Dopamine D2 receptor and serotonin 1a receptor | G-21 | HTR1A | Serotonin receptor 1A | ||
Type: | n/a | ||
Mol. Mass.: | 46122.49 | ||
Organism: | Homo sapiens (Human) | ||
Description: | n/a | ||
Residue: | 422 | ||
Sequence: |
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BDBM50207152 | |||
n/a | |||
Name | BDBM50207152 | ||
Synonyms: | CHEMBL3971907 | ||
Type | Small organic molecule | ||
Emp. Form. | C23H35N5OS | ||
Mol. Mass. | 429.622 | ||
SMILES | CCN(C)C(=O)N[C@H]1CC[C@H](CCN2CCN(CC2)c2nsc3ccccc23)CC1 |r,wU:7.6,wD:10.10,(10.36,-14.68,;9.54,-15.96,;10.26,-17.34,;9.38,-18.63,;11.75,-17.4,;12.46,-18.78,;12.51,-16.06,;14.05,-16.06,;14.82,-14.73,;16.36,-14.73,;17.13,-16.06,;18.67,-16.06,;19.44,-14.73,;20.98,-14.73,;21.75,-13.39,;23.29,-13.39,;24.05,-14.73,;23.29,-16.06,;21.75,-16.06,;25.59,-14.73,;26.52,-16.01,;28.01,-15.5,;28.01,-13.96,;29.07,-12.93,;28.77,-11.44,;27.34,-10.98,;26.21,-12.01,;26.52,-13.49,;16.36,-17.4,;14.82,-17.4,)| | ||
Structure |