Reaction Details |
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Target | Carbonic anhydrase 12 |
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Ligand | BDBM50207548 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1632055 (CHEMBL3874761) |
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Ki | 8.9±n/a nM |
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Citation | Bozdag, M; Alafeefy, AM; Altamimi, AM; Vullo, D; Carta, F; Supuran, CT Coumarins and other fused bicyclic heterocycles with selective tumor-associated carbonic anhydrase isoforms inhibitory activity. Bioorg Med Chem25:677-683 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Carbonic anhydrase 12 |
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Name: | Carbonic anhydrase 12 |
Synonyms: | CA-XII | CA12 | CAH12_HUMAN | Carbonate dehydratase XII | Carbonic anhydrase | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3 |
Type: | Enzyme |
Mol. Mass.: | 39456.00 |
Organism: | Homo sapiens (Human) |
Description: | Catalytic domain of human cloned isozyme was used in the assay |
Residue: | 354 |
Sequence: | MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDL
HSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHL
HWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFN
PSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFR
NPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGL
SLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
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BDBM50207548 |
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n/a |
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Name | BDBM50207548 |
Synonyms: | CHEMBL3977549 |
Type | Small organic molecule |
Emp. Form. | C24H17ClN2O4 |
Mol. Mass. | 432.856 |
SMILES | Cc1cc(=O)oc2cc(NC(=O)c3ccccc3NC(=O)c3ccc(Cl)cc3)ccc12 |
Structure |
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