| Reaction Details |
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 | Report a problem with these data |
| Target | DNA gyrase subunit B |
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| Ligand | BDBM50208265 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1632525 (CHEMBL3875317) |
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| IC50 | 28300±n/a nM |
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| Citation |  Chaudhari, K; Surana, S; Jain, P; Patel, HM Mycobacterium Tuberculosis (MTB) GyrB inhibitors: An attractive approach for developing novel drugs against TB. Eur J Med Chem124:160-185 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| DNA gyrase subunit B |
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| Name: | DNA gyrase subunit B |
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| Synonyms: | GYRB_MYCSM | gyrB |
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| Type: | PROTEIN |
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| Mol. Mass.: | 74505.25 |
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| Organism: | Mycobacterium smegmatis |
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| Description: | ChEMBL_107961 |
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| Residue: | 675 |
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| Sequence: | MAAQKNNAPKEYGADSITILEGLEAVRKRPGMYIGSTGERGLHHLIWEVVDNAVDEAMAG
FATRVDVKIHADGSVEVRDDGRGIPVEMHATGMPTIDVVMTQLHAGGKFDGETYAVSGGL
HGVGVSVVNALSTRLEATVLRDGYEWFQYYDRSVPGKLKQGGETKETGTTIRFWADPEIF
ETTDYNFETVARRLQEMAFLNKGLTIELTDERVTAEEVVDDVVKDTAEAPKTADEKAAEA
TGPSKVKHRVFHYPGGLVDYVKHINRTKTPIQQSIIDFDGKGPGHEVEIAMQWNAGYSES
VHTFANTINTHEGGTHEEGFRAALTSVVNRYAKDKKLLKDKDPNLTGDDIREGLAAVISV
KVAEPQFEGQTKTKLGNTEVKSFVQKICNEQLQHWFEANPAEAKTVVNKAVSSAQARIAA
RKARELVRRKSATDIGGLPGKLADCRSTDPSKSELYVVEGDSAGGSAKSGRDSMFQAILP
LRGKIINVEKARIDRVLKNTEVQSIITALGTGIHDEFDISKLRYHKIVLMADADVDGQHI
STLLLTLLFRFMKPLVENGHIFLAQPPLYKLKWQRSEPEFAYSDRERDGLLEAGRAAGKK
INVDDGIQRYKGLGEMDAKELWETTMDPSVRVLRQVTLDDAAAADELFSILMGEDVEARR
SFITRNAKDVRFLDV
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| BDBM50208265 |
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| n/a |
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| Name | BDBM50208265 |
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| Synonyms: | CHEMBL3884787 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H32N4O3 |
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| Mol. Mass. | 484.5894 |
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| SMILES | Cc1ccc2N(CCN3CCN(CC3)NCc3ccccc3OCc3ccccc3)C(=O)C(=O)c2c1 |
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| Structure | 
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