Reaction Details |
| Report a problem with these data |
Target | DNA gyrase subunit B |
---|
Ligand | BDBM50208288 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1632525 (CHEMBL3875317) |
---|
IC50 | 69700±n/a nM |
---|
Citation | Chaudhari, K; Surana, S; Jain, P; Patel, HM Mycobacterium Tuberculosis (MTB) GyrB inhibitors: An attractive approach for developing novel drugs against TB. Eur J Med Chem124:160-185 (2016) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
DNA gyrase subunit B |
---|
Name: | DNA gyrase subunit B |
Synonyms: | GYRB_MYCSM | gyrB |
Type: | PROTEIN |
Mol. Mass.: | 74505.25 |
Organism: | Mycobacterium smegmatis |
Description: | ChEMBL_107961 |
Residue: | 675 |
Sequence: | MAAQKNNAPKEYGADSITILEGLEAVRKRPGMYIGSTGERGLHHLIWEVVDNAVDEAMAG
FATRVDVKIHADGSVEVRDDGRGIPVEMHATGMPTIDVVMTQLHAGGKFDGETYAVSGGL
HGVGVSVVNALSTRLEATVLRDGYEWFQYYDRSVPGKLKQGGETKETGTTIRFWADPEIF
ETTDYNFETVARRLQEMAFLNKGLTIELTDERVTAEEVVDDVVKDTAEAPKTADEKAAEA
TGPSKVKHRVFHYPGGLVDYVKHINRTKTPIQQSIIDFDGKGPGHEVEIAMQWNAGYSES
VHTFANTINTHEGGTHEEGFRAALTSVVNRYAKDKKLLKDKDPNLTGDDIREGLAAVISV
KVAEPQFEGQTKTKLGNTEVKSFVQKICNEQLQHWFEANPAEAKTVVNKAVSSAQARIAA
RKARELVRRKSATDIGGLPGKLADCRSTDPSKSELYVVEGDSAGGSAKSGRDSMFQAILP
LRGKIINVEKARIDRVLKNTEVQSIITALGTGIHDEFDISKLRYHKIVLMADADVDGQHI
STLLLTLLFRFMKPLVENGHIFLAQPPLYKLKWQRSEPEFAYSDRERDGLLEAGRAAGKK
INVDDGIQRYKGLGEMDAKELWETTMDPSVRVLRQVTLDDAAAADELFSILMGEDVEARR
SFITRNAKDVRFLDV
|
|
|
BDBM50208288 |
---|
n/a |
---|
Name | BDBM50208288 |
Synonyms: | CHEMBL3884713 |
Type | Small organic molecule |
Emp. Form. | C29H32N4O4 |
Mol. Mass. | 500.5888 |
SMILES | COc1ccc2N(CCN3CCN(CC3)NCc3ccccc3OCc3ccccc3)C(=O)C(=O)c2c1 |
Structure |
|