| Reaction Details |
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 | Report a problem with these data |
| Target | DNA gyrase subunit A |
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| Ligand | BDBM50211507 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1636458 (CHEMBL3879356) |
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| IC50 | 842±n/a nM |
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| Citation |  Alagumuthu, M; Arumugam, S Molecular docking, discovery, synthesis, and pharmacological properties of new 6-substituted-2-(3-phenoxyphenyl)-4-phenyl quinoline derivatives; an approach to developing potent DNA gyrase inhibitors/antibacterial agents. Bioorg Med Chem25:1448-1455 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| DNA gyrase subunit A |
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| Name: | DNA gyrase subunit A |
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| Synonyms: | DNA gyrase subunit A (gyrA) | GYRA_STAAU | gyrA |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 99588.82 |
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| Organism: | Staphylococcus aureus |
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| Description: | n/a |
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| Residue: | 889 |
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| Sequence: | MAELPQSRINERNITSEMRESFLDYAMSVIVARALPDVRDGLKPVHRRILYGLNEQGMTP
DKSYKKSARIVGDVMGKYHPHGDSSIYEAMVRMAQDFSYRYPLVDGQGNFGSMDGDGAAA
MRYTEARMTKITLELLRDINKDTIDFIDNYDGNEREPSVLPARFPNLLANGASGIAVGMA
TNIPPHNLTELINGVLSLSKNPDISIAELMEDIEGPDFPTAGLILGKSGIRRAYETGRGS
IQMRSRAVIEERGGGRQRIVVTEIPFQVNKARMIEKIAELVRDKKIDGITDLRDETSLRT
GVRVVIDVRKDANASVILNNLYKQTPLQTSFGVNMIALVNGRPKLINLKEALVHYLEHQK
TVVRRRTQYNLRKAKDRAHILEGLRIALDHIDEIISTIRESDTDKVAMESLQQRFKLSEK
QAQAILDMRLRRLTGLERDKIEAEYNELLNYISELEAILADEEVLLQLVRDELTEIRDRF
GDDRRTEIQLGGFEDLEDEDLIPEEQIVITLSHNNYIKRLPVSTYRAQNRGGRGVQGMNT
LEEDFVSQLVTLSTHDHVLFFTNKGRVYKLKGYEVPELSRQSKGIPVVNAIELENDEVIS
TMIAVKDLESEDNFLVFATKRGVVKRSALSNFSRINRNGKIAISFREDDELIAVRLTSGQ
EDILIGTSHASLIRFPESTLRPLGRTATGVKGITLREGDEVVGLDVAHANSVDEVLVVTE
NGYGKRTPVNDYRLSNRGGKGIKTATITERNGNVVCITTVTGEEDLMIVTNAGVIIRLDV
ADISQNGRAAQGVRLIRLGDDQFVSTVAKVKEDAEDETNEDEQSTSTVSEDGTEQQREAV
VNDETPGNAIHTEVIDSEENDEDGRIEVRQDFMDRVEEDIQQSLDEDEE
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| BDBM50211507 |
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| n/a |
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| Name | BDBM50211507 |
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| Synonyms: | CHEMBL3908837 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H19NO2 |
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| Mol. Mass. | 389.4453 |
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| SMILES | Oc1ccc2nc(cc(-c3ccccc3)c2c1)-c1cccc(Oc2ccccc2)c1 |
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| Structure | 
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