Ki Summary

Reaction Details

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Target

5-hydroxytryptamine receptor 3A/3B

Ligand

BDBM50212855

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_3391 (CHEMBL619421)

10.0±n/a nM

Citation

TBA Bioorg Med Chem Lett3:1375-1378 (1993)

More Info.:

Get all data from this article, Assay Method

5-hydroxytryptamine receptor 3A/3B

Name:

5-hydroxytryptamine receptor 3A/3B

Synonyms:

Serotonin 3 (5-HT3) receptor | Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor

Type:

n/a

Mol. Mass.:

n/a

Description:

ASSAY_ID of EBI is 2974

Components:

This complex has 2 components.

Component 1

Name:

5-hydroxytryptamine receptor 3B

Synonyms:

5HT3B_RAT | Htr3b | Serotonin (5-HT) receptor

Type:

PROTEIN

Mol. Mass.:

50328.78

Organism:

Rattus norvegicus

Description:

EBI_11885

Residue:

437

Sequence:

MILLWSCLLVAVVGILGTATPQPGNSSLHRLTRQLLQQYHKEVRPVYNWAEATTVYLDLC
VHAVLDVDVQNQKLKTSMWYREVWNDEFLSWNSSLFDDIQEISLPLSAIWAPDIIINEFV
DVERSPDLPYVYVNSSGTIRNHKPIQVVSACSLQTYAFPFDIQNCSLTFNSILHTVEDID
LGFLRNQEDIENDKRSFLNDSEWQLLSVTSTYHIRQSSAGDFAQIRFNVVIRRCPLAYVV
SLLIPSIFLMLVDLGSFYLPPNCRARIVFKTNVLVGYTVFRVNMSDEVPRSAGCTSLIGV
FFTVCMALLVLSLSKSILLIKFLYEERHSEQERPLMCLRGDSDANESRLYLRAPCAEDTE
SPVRQEHQVPSDTLKDFWFQLQSINNSLRTRDQVYQKEVEWLAILCHFDQLLFRIYLAVL
GLYTVTLCSLWALWSRM

Component 2

Name:

5-hydroxytryptamine receptor 3A

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

55428.70

Organism:

RAT

Description:

5-HT3 HTR3A RAT::P35563

Residue:

483

Sequence:

MPLCIPQVLLALFLSVLIAQGEGSRRRATQAHSTTQPALLRLSDHLLANYKKGVRPVRDW
RKPTLVSIDVIMYAILNVDEKNQVLTTYIWYRQFWTDEFLQWTPEDFDNVTKLSIPTDSI
WVPDILINEFVDVGKSPSIPYVYVHHQGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTF
TSWLHTIQDINISLWRTPEEVRSDKSIFINQGEWELLGVFTKFQEFSIETSNSYAEMKFY
VVIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTL
PATAIGTPLIGVYFVVCMALLVISLAETIFIVQLVHKQDLQRPVPDWLRHLVLDRIAWLL
CLGEQPMAHRPPATFQANKTDDCSAMGNHCSHVGSPQDLEKTSRSRDSPLPPPREASLAV
RGLLQELSSIRHSLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIW
HYS

BDBM50212855

n/a

Name

BDBM50212855

Synonyms:

CHEMBL28499

Type

Small organic molecule

Emp. Form.

C19H18ClN3O2

Mol. Mass.

355.818

SMILES

[H][C@]1(CN2CCC1CC2)N1C(=O)c2cccc3c(N)c(Cl)cc(C1=O)c23 |wU:1.0,wD:1.10,THB:9:1:5.4:7.8,(6.83,1.19,;7.23,-.29,;8.25,.72,;10.09,1.11,;10.32,2.17,;9.33,1.54,;9.03,.2,;10.37,-1.08,;11.41,-.14,;5.85,-1.01,;5.9,-2.62,;7.25,-3.37,;4.57,-3.39,;4.61,-4.92,;3.26,-5.71,;1.93,-4.94,;1.92,-3.4,;.58,-2.63,;-.76,-3.4,;.58,-1.08,;-.75,-.31,;1.92,-.31,;3.25,-1.11,;4.56,-.33,;4.54,1.22,;3.26,-2.63,)|

Structure