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TargetPhosphodiesterase/cAMP-specific 3',5'-cyclic phosphodiesterase 4A/cAMP-specific 3',5'-cyclic phosphodiesterase 4C/cAMP-specific 3',5'-cyclic phosphodiesterase 4D
LigandBDBM14361
Substrate/Competitorn/a
Meas. Tech.ChEMBL_157201 (CHEMBL871977)
IC50 4±n/a nM
Citation  TBA Bioorg Med Chem Lett5:1969-1972 (1995)  
More Info.:Get all data from this article,  Assay Method
 
Phosphodiesterase/cAMP-specific 3',5'-cyclic phosphodiesterase 4A/cAMP-specific 3',5'-cyclic phosphodiesterase 4C/cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Name:Phosphodiesterase/cAMP-specific 3',5'-cyclic phosphodiesterase 4A/cAMP-specific 3',5'-cyclic phosphodiesterase 4C/cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Synonyms:Phosphodiesterase 4
Type:n/a
Mol. Mass.:n/a
Description:ASSAY_ID of ChEMBL is 157202
Components:This complex has 4 components.
Component 1
Name:cAMP-specific 3',5'-cyclic phosphodiesterase 4A
Synonyms:PDE4A_MOUSE | Pde4a
Type:PROTEIN
Mol. Mass.:93529.25
Organism:Mus musculus
Description:ChEMBL_105062
Residue:844
Sequence:
MEPPAAPSERSLSLSLPGPREGQATLKPPPQHLWRQPRTPIRIQQRGYSDSAERSEPERS
PHRPIERADAVDTGDRPGLRTTRMSWPSSFHGTGTGGGSSRRLEAENGPTPSPGRSPLDS
QASPGLMLHAGAATSQRRESFLYRSDSDYDMSPKTMSRNSSVASEAHGEDLIVTPFAQVL
ASLRNVRSNFSLLTNVPIPSNKRSPLGGPPSVCKATLSEETCQQLARETLEELDWCLEQL
ETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQHEVEIPSPTP
RQRPFQQPPPAAVQQAQPMSQITGLKKLVHTGSLNINVPRFGVKTDQEDLLAQELENLSK
WGLNIFCVSEYAGGRSLSCIMYTIFQERDLLKKFHIPVDTMMTYMLTLEDHYHADVAYHN
SLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELAL
MYNDESVLENHHLAVGFKLLQEENCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLA
DLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFF
QQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLED
NRDWYHSAIRQSPSPTLEEEPGVLSDPALPDKFQFELTLEEEDEEDSLEVPGLPCTEETL
LAPHDTRAQAMEQSKVKGQSPAVVEVAESLKQETASAHGAPEESAEAVGHSFSLETSILP
DLRTLSPSEEAQGLLGLPSMAAEVEAPRDHLAAMRACSACSGTSGDNSAVISAPGRWGSG
GDPA
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Component 2
Name:Phosphodiesterase
Synonyms:Phosphodiesterase 4 (PDE4)
Type:Protein
Mol. Mass.:82059.36
Organism:Mus musculus (Mouse)
Description:Q8VBU5
Residue:721
Sequence:
MTAKNSPKEFTASESEVCIKTFKEQMRLELELPKLPGNRPTSPKISPRSSPRNSPCFFRK
LLVNKSIRQRRRFTVAHTCFDVENGPSPGRSPLDPQAGSSSGLVLHAAFPGHSQRRESFL
YRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRSVRNNFTLLTNLHGAPNK
RSPAASQAPVSRVSLQEESYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLN
RELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLM
HSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQER
DLLKTFKISSDTFVTYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLE
ILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIF
QNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQV
LRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQ
VGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDERSRDCQGLM
EKFQFELTLEEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLEETDIDIATEDKSPID
T
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Component 3
Name:cAMP-specific 3',5'-cyclic phosphodiesterase 4C
Synonyms:PDE4C_MOUSE | Pde4c
Type:PROTEIN
Mol. Mass.:76060.28
Organism:Mus musculus
Description:ChEMBL_105062
Residue:686
Sequence:
MRRSGTALSFLWTERVREPVDSGVAPVSPLGGGVILRRFSGTLLLPPLSSRLGSSGEAES
AAHVVFTIGTQGTQRNLGSAQSSFDLENGLPGGKGLLDAQSGPSLGRALQPPVHHVQRRE
SFLYRSDSDHEPSPKAVSRTSSAASDLHGEDMIVTPFAQVLASLRTVRNNVAALAHGPGS
ATRQVLLGTPPHSSQQAAPTEDSGLQLVQETLEELDWCLEQLETLQTRRSVGEMASNKFK
RMLNRELSYLSETSRSGNQVSEYISQTFLDQQAEVELPQPPTEDDPWPMAQITELRRSSH
TSLPTAAIPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAVIFSVFQERDL
LKTFQIPADTLLAYLLTLEGHYHSDVAYHNSMHAADVVQSAHVLLGTPALEAVFTDLEVL
AAIFACAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQGENCDIFRN
LSTKQRLSLRRMVIDMVLATDMSKHMSLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQ
SLVHCADLSNPAKPLPLYRQWTERIMAEFFQQGDRERESGLDISPMCDKHTASMEKSQVG
FIDYIAQPLWETWADLVHPDAQELLDTLEDNREWYQSRIPCSPPHTMGSDRFKFELTLEE
AEEEEEEEDEGQCTALNRESSELPST
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Component 4
Name:cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Synonyms:DPDE3 | PDE4D_MOUSE | Pde4d
Type:PROTEIN
Mol. Mass.:84520.85
Organism:Mus musculus
Description:ChEMBL_105062
Residue:747
Sequence:
MERDTCDVLSRSKSASEETLHSCNEEEDPFRGMEPYLVRRLSSRSIQLPPLAFRQLEQAD
LRSESENIPRPTSLPLKILPLIAVTSADSSGFDVDNGTSAGRSPLDPMTSPGSGLILQAN
FVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFA
ALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHSVS
EMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQHEVEIPSPTQKEKEKKKRPM
SQISGVKKLMHSSSLTNSCIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLT
VIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTP
ALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFK
LLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLL
LDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCD
KHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPD
DQEEGRQGQTEKFQFELTLEEDCESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLD
EQVEEEAVAEEESQPETCVPDDCCPDT
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BDBM14361
n/a
NameBDBM14361
Synonyms:(R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrolidin-2-one | 4-[3-(cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one | Adeo | CHEMBL63 | Rolipram
TypeSmall organic molecule
Emp. Form.C16H21NO3
Mol. Mass.275.3428
SMILESCOc1ccc(cc1OC1CCCC1)C1CNC(=O)C1
Structure
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