| Reaction Details |
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 | Report a problem with these data |
| Target | Estrogen receptor beta |
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| Ligand | BDBM50085657 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_125044 (CHEMBL731554) |
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| EC50 | 0.960000±n/a nM |
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| Citation |  Jørgensen, AS; Jacobsen, P; Christiansen, LB; Bury, PS; Kanstrup, A; Thorpe, SM; Bain, S; Naerum, L; Wassermann, K Synthesis and pharmacology of a novel pyrrolo[2,1,5-cd] indolizine (NNC 45-0095), a high affinity non-steroidal agonist for the estrogen receptor. Bioorg Med Chem Lett10:399-402 (2000) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Estrogen receptor beta |
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| Name: | Estrogen receptor beta |
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| Synonyms: | Estrogen receptor |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | ASSAY_ID of ChEMBL is 125044 |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Estrogen receptor |
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| Synonyms: | ESR1_MOUSE | Esr | Esr1 | Estr | Estra | Estrogen receptor alpha | Nr3a1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 66969.87 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_648798 |
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| Residue: | 599 |
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| Sequence: | MTMTLHTKASGMALLHQIQGNELEPLNRPQLKMPMERALGEVYVDNSKPTVFNYPEGAAY
EFNAAAAAAAAASAPVYGQSGIAYGPGSEAAAFSANSLGAFPQLNSVSPSPLMLLHPPPQ
LSPFLHPHGQQVPYYLENEPSAYAVRDTGPPAFYRSNSDNRRQNGRERLSSSNEKGNMIM
ESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKS
CQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDLEGRNEMGASGDMRAANLWPSPL
VIKHTKKNSPALSLTADQMVSALLDAEPPMIYSEYDPSRPFSEASMMGLLTNLADRELVH
MINWAKRVPGFGDLNLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGK
CVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIH
RVLDKITDTLIHLMAKAGLTLQQQHRRLAQLLLILSHIRHMSNKGMEHLYNMKCKNVVPL
YDLLLEMLDAHRLHAPASRMGVPPEEPSQTQLATTSSTSAHSLQTYYIPPEAEGFPNTI
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| Component 2 |
| Name: | Estrogen receptor beta |
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| Synonyms: | ER-beta | ESR2_MOUSE | Esr2 | Estrb | Estrb | Estrogen receptor | Estrogen receptor beta | Nr3a2 | Nuclear receptor subfamily 3 group A member 2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 59091.81 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_306448 |
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| Residue: | 530 |
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| Sequence: | MEIKNSPSSLTSPASYNCSQSILPLEHGPIYIPSSYVESRHEYSAMTFYSPAVMNYSVPS
STGNLEGGPVRQTASPNVLWPTSGHLSPLATHCQSSLLYAEPQKSPWCEARSLEHTLPVN
RETLKRKLGGSGCASPVTSPSAKRDAHFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGH
NDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRIVRRQRSASEQVH
CLNKAKRTSGHTPRVKELLLNSLSPEQLVLTLLEAEPPNVLVSRPSMPFTEASMMMSLTK
LADKELVHMIGWAKKIPGFVELSLLDQVRLLESCWMEVLMVGLMWRSIDHPGKLIFAPDL
VLDRDEGKCVEGILEIFDMLLATTARFRELKLQHKEYLCVKAMILLNSSMYPLATASQEA
ESSRKLTHLLNAVTDALVWVISKSGISSQQQSVRLANLLMLLSHVRHISNKGMEHLLSMK
CKNVVPVYDLLLEMLNAHTLRGYKSSISGSECCSTEDSKSKEGSQNLQSQ
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| BDBM50085657 |
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| n/a |
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| Name | BDBM50085657 |
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| Synonyms: | 4-(1-Ethyl-pyrrolo[2,1,5-cd]indolizin-2-yl)-phenol | CHEMBL420017 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H15NO |
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| Mol. Mass. | 261.3178 |
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| SMILES | CCc1c(-c2ccc(O)cc2)c2ccc3cccc1n23 |
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| Structure | 
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