| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tubulin alpha-1A/beta chain |
|---|
| Ligand | BDBM50095321 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_211688 (CHEMBL819859) |
|---|
| IC50 | 4000±n/a nM |
|---|
| Citation |  Lawrence, NJ; Rennison, D; Woo, M; McGown, AT; Hadfield, JA Antimitotic and cell growth inhibitory properties of combretastatin A-4-like ethers. Bioorg Med Chem Lett11:51-4 (2001) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tubulin alpha-1A/beta chain |
|---|
| Name: | Tubulin alpha-1A/beta chain |
|---|
| Synonyms: | Tubulin |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | n/a |
|---|
| Description: | ASSAY_ID of ChEMBL is 1437750 |
|---|
| Components: | This complex has 2 components. |
|---|
| Component 1 |
| Name: | Tubulin alpha-1A chain |
|---|
| Synonyms: | TBA1A_PIG | TUBA1A | Tubulin | Tubulin alpha chain | Tubulin alpha-1A chain |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 50049.25 |
|---|
| Organism: | Sus scrofa (Pig) |
|---|
| Description: | P02550 |
|---|
| Residue: | 451 |
|---|
| Sequence: | MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGK
HVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLD
RIRKLADQCTGLQGFSVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTA
VVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITA
SLRFDGALNVDLTEFQTNLVPYPRAHFPLATYAPVISAEKAYHEQLSVAEITNACFEPAN
QMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYEPP
TVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSE
AREDMAALEKDYEEVGVDSVEGEGEEEGEEY
|
|
|
|---|
| Component 2 |
| Name: | Tubulin beta chain |
|---|
| Synonyms: | Beta-tubulin | TBB_PIG | Tubulin beta chain |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 49840.26 |
|---|
| Organism: | Sus scrofa |
|---|
| Description: | ChEMBL_105107 |
|---|
| Residue: | 445 |
|---|
| Sequence: | MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEAAGNKYV
PRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV
RKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVV
EPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMM
AACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG
LKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATADEQGEFEEEGEEDEA
|
|
|
|---|
| BDBM50095321 |
|---|
| n/a |
|---|
| Name | BDBM50095321 |
|---|
| Synonyms: | 2-Methoxy-5-(3,4,5-trimethoxy-benzyloxy)-benzaldehyde | CHEMBL150582 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H20O6 |
|---|
| Mol. Mass. | 332.3478 |
|---|
| SMILES | COc1ccc(OCc2cc(OC)c(OC)c(OC)c2)cc1C=O |
|---|
| Structure | 
|
|---|
Search and Browse
