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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | cAMP-specific 3',5'-cyclic phosphodiesterase 4C | ||
| Ligand | BDBM50346088 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_192810 (CHEMBL798530) | ||
| IC50 | 180±n/a nM | ||
| Citation |  Nam, G; Yoon, CM; Kim, E; Rhee, CK; Kim, JH; Shin, JH; Kim, SH Syntheses and evaluation of pyrido[2,3-dlpyrimidine-2,4-diones as PDE 4 inhibitors. Bioorg Med Chem Lett11:611-4 (2001) [PubMed] | ||
| More Info.: | Get all data from this article, Assay Method | ||
| cAMP-specific 3',5'-cyclic phosphodiesterase 4C | |||
| Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4C | ||
| Synonyms: | Dpde1 | PDE4C_RAT | Pde4c | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 60038.21 | ||
| Organism: | Rattus norvegicus | ||
| Description: | ChEMBL_104732 | ||
| Residue: | 536 | ||
| Sequence: |
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| BDBM50346088 | |||
| n/a | |||
| Name | BDBM50346088 | ||
| Synonyms: | (1r,4r)-4-cyano-4-(3-(cyclopentyloxy)-4-methoxyphenyl)cyclohexanecarboxylic acid | 4-Cyano-3-cyclopentyloxy-4-(4-methoxy-phenyl)-cyclohexanecarboxylic acid | 4-Cyano-4-(3-cyclopentyloxy-4-methoxy-phenyl)-cyclohexanecarboxylic acid | 4-Cyano-4-(3-cyclopentyloxy-4-methoxy-phenyl)-cyclohexanecarboxylic acid (Ariflo) | 4-Cyano-4-(3-cyclopentyloxy-4-methoxy-phenyl)-cyclohexanecarboxylic acid methyl ester | 4-Cyano-4-(3-cyclopentyloxy-4-methoxy-phenyl)-cyclohexanecarboxylic acid(Ariflo) | 6-(3,4-Dimethoxy-phenyl)-5-methyl-4,5-dihydro-2H-pyridazin-3-one | Ariflo | CHEMBL511115 | SB-207499 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H25NO4 | ||
| Mol. Mass. | 343.4168 | ||
| SMILES | COc1ccc(cc1OC1CCCC1)[C@]1(CC[C@@H](CC1)C(O)=O)C#N |r,wU:17.22,14.25,(4.79,2.97,;3.46,3.74,;2.12,2.97,;.79,3.74,;-.54,2.97,;-.54,1.43,;.79,.66,;2.12,1.43,;3.46,.66,;3.46,-.88,;4.7,-1.79,;4.23,-3.25,;2.69,-3.25,;2.21,-1.79,;-1.88,.66,;-3.42,.71,;-4.23,-.6,;-3.51,-1.96,;-1.97,-2.01,;-1.16,-.7,;-4.33,-3.26,;-3.6,-4.62,;-5.87,-3.21,;-1.77,2.19,;-1.66,3.73,)| | ||
| Structure | 
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