| Reaction Details |
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 | Report a problem with these data |
| Target | cAMP-specific 3',5'-cyclic phosphodiesterase 4C |
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| Ligand | BDBM50219193 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_157223 (CHEMBL769547) |
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| IC50 | 2310±n/a nM |
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| Citation |  Nam, G; Yoon, CM; Kim, E; Rhee, CK; Kim, JH; Shin, JH; Kim, SH Syntheses and evaluation of pyrido[2,3-dlpyrimidine-2,4-diones as PDE 4 inhibitors. Bioorg Med Chem Lett11:611-4 (2001) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4C |
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| Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4C |
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| Synonyms: | Dpde1 | PDE4C_RAT | Pde4c |
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| Type: | PROTEIN |
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| Mol. Mass.: | 60038.21 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_104732 |
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| Residue: | 536 |
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| Sequence: | NSSRTSSAASDLHGEDMIVTPFAQVLASLRTVRSNVAALAHGAGSATRQALLGTPPQSSQ
QAAPAEESGLQLAQETLEELDWCLEQLETLQTRRSVGEMASNKFKRMLNRELTHLSETSR
SGNQVSEYISQTFLDQQAEVELPAPPTEDHPWPMAQITGLRKSCHTSLPTAAIPRFGVQT
DQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAVIFRVLQERDLLKTFQIPADTLLRYL
LTLEGHYHSNVAYHNSIHAADVVQSAHVLLGTPALEAVFTDLEVLAAIFACAIHDVDHPG
VSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQGENCDIFQNLSTKQKLSLRRMVID
MVLATDMSKHMSLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQSLVHCADLSNPAKPL
PLYRQWTERIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWAD
LVHPDAQELLDTLEDNREWYQSRVPCSPPHAIGPDRFKFELTLEETEEEEEEDERH
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| BDBM50219193 |
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| n/a |
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| Name | BDBM50219193 |
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| Synonyms: | CHEMBL158266 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H16F3N3O2 |
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| Mol. Mass. | 411.3765 |
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| SMILES | Cn1c2ncc(cc2c(=O)n(Cc2ccccc2)c1=O)-c1ccccc1C(F)(F)F |
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| Structure | 
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