Reaction Details |
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Target | Corticotropin-releasing factor receptor 1/2 |
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Ligand | BDBM50220495 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_50970 (CHEMBL666051) |
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Ki | 2.8±n/a nM |
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Citation | Arvanitis, AG; Rescinito, JT; Arnold, CR; Wilde, RG; Fitzgerald, LW; Zaczek, R; Hartig, PR; Grossman, S; Arneric, SP; Gilligan, PJ; Olson, RE; Robertson, DW Imidazo[4,5-c]pyridines as corticotropin releasing factor receptor ligands. Bioorg Med Chem Lett13:129-31 (2003) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Corticotropin-releasing factor receptor 1/2 |
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Name: | Corticotropin-releasing factor receptor 1/2 |
Synonyms: | Corticotropin releasing factor receptor |
Type: | n/a |
Mol. Mass.: | n/a |
Description: | ASSAY_ID of ChEMBL is 217368 |
Components: | This complex has 2 components. |
Component 1 |
Name: | Corticotropin-releasing factor receptor 1 |
Synonyms: | CRF-R | CRF1 | CRFR1_RAT | CRH-R 1 | Corticotropin releasing factor receptor | Corticotropin releasing factor receptor 1 | Corticotropin-releasing Factor Receptor 1 | Corticotropin-releasing hormone receptor 1 | Crhr | Crhr1 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 47870.75 |
Organism: | Rattus norvegicus (rat) |
Description: | Receptor binding assays were performed using rat cortex homogenate. |
Residue: | 415 |
Sequence: | MGRRPQLRLVKALLLLGLNPVSTSLQDQRCENLSLTSNVSGLQCNASVDLIGTCWPRSPA
GQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAV
IINYLGHCISLVALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTVSPEV
HQSNVAWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFVCIGWGVPF
PIIVAWAIGKLHYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRA
STTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVS
VFYCFLNSEVRSAIRKRWRRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
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Component 2 |
Name: | Corticotropin-releasing factor receptor 2 |
Synonyms: | CRF-R-2 | CRF-R2 | CRF2 Beta | CRFR-2 | CRFR2_RAT | CRH-R-2 | CRH-R2 | Corticotropin releasing factor receptor | Corticotropin-releasing factor receptor 2 | Corticotropin-releasing hormone receptor 2 | Crf2r | Crhr2 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 47697.09 |
Organism: | RAT |
Description: | CRF2 Beta 0 RAT::P47866 |
Residue: | 411 |
Sequence: | MDAALLLSLLEANCSLALAEELLLDGWGEPPDPEGPYSYCNTTLDQIGTCWPQSAPGALV
ERPCPEYFNGIKYNTTRNAYRECLENGTWASRVNYSHCEPILDDKQRKYDLHYRIALIIN
YLGHCVSVVALVAAFLLFLVLRSIRCLRNVIHWNLITTFILRNITWFLLQLIDHEVHEGN
EVWCRCVTTIFNYFVVTNFFWMFVEGCYLHTAIVMTYSTEHLRKWLFLFIGWCIPCPIIV
AWAVGKLYYENEQCWFGKEPGDLVDYIYQGPIILVLLINFVFLFNIVRILMTKLRASTTS
ETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDDLSQIVFIYFNSFLQSFQGFFVSVFYC
FFNGEVRSALRKRWHRWQDHHALRVPVARAMSIPTSPTRISFHSIKQTAAV
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BDBM50220495 |
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n/a |
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Name | BDBM50220495 |
Synonyms: | CHEMBL26610 |
Type | Small organic molecule |
Emp. Form. | C20H21ClF3N3O |
Mol. Mass. | 411.848 |
SMILES | CCCC(C)n1c(CC)nc2c(nccc12)-c1ccc(OC(F)(F)F)cc1Cl |
Structure |
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