| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Inosine-5'-monophosphate dehydrogenase 1/2 |
|---|
| Ligand | BDBM50222697 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_89673 (CHEMBL697166) |
|---|
| Ki | 62000±n/a nM |
|---|
| Citation |  Nair, V; Kamboj, RC Inhibition of inosine monophosphate dehydrogenase (IMPDH) by 2-[2-(Z)-fluorovinyl]inosine 5'-monophosphate. Bioorg Med Chem Lett13:645-7 (2003) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Inosine-5'-monophosphate dehydrogenase 1/2 |
|---|
| Name: | Inosine-5'-monophosphate dehydrogenase 1/2 |
|---|
| Synonyms: | Inosine-5''''-monophosphate dehydrogenase (IMPDH) | Inosine-5''-monophosphate dehydrogenase (IMPDH) | Inosine-5'-monophosphate dehydrogenase (IMPDH) |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | n/a |
|---|
| Description: | ASSAY_ID of ChEMBL is 88591 |
|---|
| Components: | This complex has 2 components. |
|---|
| Component 1 |
| Name: | Inosine-5'-monophosphate dehydrogenase 2 |
|---|
| Synonyms: | IMDH2_HUMAN | IMP dehydrogenase 2 | IMPD 2 | IMPD2 | IMPDH-II | IMPDH2 | Inosine 5'-monophosphate dehydrogenase II (IMPDH II) | Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2) | Inosine-5 -monophosphate dehydrogenase 2 | Inosine-5'-monophosphate dehydrogenase (IMPDH) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 55806.87 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Recombinant IMPDH2 expressed in E. coli. |
|---|
| Residue: | 514 |
|---|
| Sequence: | MADYLISGGTSYVPDDGLTAQQLFNCGDGLTYNDFLILPGYIDFTADQVDLTSALTKKIT
LKTPLVSSPMDTVTEAGMAIAMALTGGIGFIHHNCTPEFQANEVRKVKKYEQGFITDPVV
LSPKDRVRDVFEAKARHGFCGIPITDTGRMGSRLVGIISSRDIDFLKEEEHDCFLEEIMT
KREDLVVAPAGITLKEANEILQRSKKGKLPIVNEDDELVAIIARTDLKKNRDYPLASKDA
KKQLLCGAAIGTHEDDKYRLDLLAQAGVDVVVLDSSQGNSIFQINMIKYIKDKYPNLQVI
GGNVVTAAQAKNLIDAGVDALRVGMGSGSICITQEVLACGRPQATAVYKVSEYARRFGVP
VIADGGIQNVGHIAKALALGASTVMMGSLLAATTEAPGEYFFSDGIRLKKYRGMGSLDAM
DKHLSSQNRYFSEADKIKVAQGVSGAVQDKGSIHKFVPYLIAGIQHSCQDIGAKSLTQVR
AMMYSGELKFEKRTSSAQVEGGVHSLHSYEKRLF
|
|
|
|---|
| Component 2 |
| Name: | Inosine-5'-monophosphate dehydrogenase 1 |
|---|
| Synonyms: | IMDH1_HUMAN | IMP dehydrogenase 1 | IMPD 1 | IMPD1 | IMPDH-I | IMPDH1 | Inosine Monophosphate Dehydrogenase Type 1 (IMPDH1) | Inosine-5'-monophosphate dehydrogenase (IMPDH) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 55407.70 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Recombinant IMPDH1 expressed in E. coli. |
|---|
| Residue: | 514 |
|---|
| Sequence: | MADYLISGGTGYVPEDGLTAQQLFASADGLTYNDFLILPGFIDFIADEVDLTSALTRKIT
LKTPLISSPMDTVTEADMAIAMALMGGIGFIHHNCTPEFQANEVRKVKKFEQGFITDPVV
LSPSHTVGDVLEAKMRHGFSGIPITETGTMGSKLVGIVTSRDIDFLAEKDHTTLLSEVMT
PRIELVVAPAGVTLKEANEILQRSKKGKLPIVNDCDELVAIIARTDLKKNRDYPLASKDS
QKQLLCGAAVGTREDDKYRLDLLTQAGVDVIVLDSSQGNSVYQIAMVHYIKQKYPHLQVI
GGNVVTAAQAKNLIDAGVDGLRVGMGCGSICITQEVMACGRPQGTAVYKVAEYARRFGVP
IIADGGIQTVGHVVKALALGASTVMMGSLLAATTEAPGEYFFSDGVRLKKYRGMGSLDAM
EKSSSSQKRYFSEGDKVKIAQGVSGSIQDKGSIQKFVPYLIAGIQHGCQDIGARSLSVLR
SMMYSGELKFEKRTMSAQIEGGVHGLHSYEKRLY
|
|
|
|---|
| BDBM50222697 |
|---|
| n/a |
|---|
| Name | BDBM50222697 |
|---|
| Synonyms: | 6-Cl-Purine Ribotide | CHEMBL1683023 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C10H12ClN4O7P |
|---|
| Mol. Mass. | 366.652 |
|---|
| SMILES | O[C@@H]1[C@@H](COP(O)(O)=O)O[C@H]([C@@H]1O)n1cnc2c(Cl)ncnc12 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
