Reaction Details |
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Target | Presenilin-1 |
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Ligand | BDBM50125397 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_68893 (CHEMBL678615) |
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IC50 | >2500±n/a nM |
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Citation | Prasad, CV; Wallace, OB; Noonan, JW; Sloan, CP; Lau, W; Vig, S; Parker, MF; Smith, DW; Hansel, SB; Polson, CT; Barten, DM; Felsenstein, KM; Roberts, SB Hydroxytriamides as potent gamma-secretase inhibitors. Bioorg Med Chem Lett14:1917-21 (2004) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Presenilin-1 |
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Name: | Presenilin-1 |
Synonyms: | 3.4.23.- | AD3 | Gamma-Secretase Subunit Presenilin-1 | PS-1 | PS1 | PS1-CTF12 | PSEN1 | PSN1_HUMAN | PSNL1 | Presenilin-1 CTF subunit | Presenilin-1 CTF12 | Presenilin-1 NTF subunit | Protein S182 |
Type: | n/a |
Mol. Mass.: | 52657.13 |
Organism: | Homo sapiens (Human) |
Description: | P49768 |
Residue: | 467 |
Sequence: | MTELPAPLSYFQNAQMSEDNHLSNTVRSQNDNRERQEHNDRRSLGHPEPLSNGRPQGNSR
QVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTE
DTETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFI
YLGEVFKTYNVAVDYITVALLIWNFGVVGMISIHWKGPLRLQQAYLIMISALMALVFIKY
LPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVWLVNMAE
GDPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEWEAQRDSHLGPHRSTPESRAA
VQELSSSILAGEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCL
TLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQLAFHQFYI
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BDBM50125397 |
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n/a |
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Name | BDBM50125397 |
Synonyms: | CHEMBL59484 |
Type | Small organic molecule |
Emp. Form. | C28H46N4O3 |
Mol. Mass. | 486.6898 |
SMILES | CCCCN(C)C(=O)[C@H](CC1CCCCC1)NC(=O)[C@H](CC(C)C)NC(=O)Cc1cccc(N)c1 |
Structure |
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