| Reaction Details |
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 | Report a problem with these data |
| Target | cAMP-specific 3',5'-cyclic phosphodiesterase 4C |
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| Ligand | BDBM10847 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_155708 (CHEMBL760586) |
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| Ki | 523000±n/a nM |
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| Comments | 53000 20220122 |
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| Citation |  Temple, DL; Yevich, JP; Catt, JD; Owens, D; Hanning, C; Covington, RR; Seidehamel, RJ; Dungan, KW Substituted 6,7-dihydroimidazo[1,2-a]purin-9(4H)-ones. J Med Chem23:1188-98 (1980) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| cAMP-specific 3',5'-cyclic phosphodiesterase 4C |
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| Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4C |
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| Synonyms: | Dpde1 | PDE4C_RAT | Pde4c |
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| Type: | PROTEIN |
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| Mol. Mass.: | 60038.21 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_104732 |
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| Residue: | 536 |
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| Sequence: | NSSRTSSAASDLHGEDMIVTPFAQVLASLRTVRSNVAALAHGAGSATRQALLGTPPQSSQ
QAAPAEESGLQLAQETLEELDWCLEQLETLQTRRSVGEMASNKFKRMLNRELTHLSETSR
SGNQVSEYISQTFLDQQAEVELPAPPTEDHPWPMAQITGLRKSCHTSLPTAAIPRFGVQT
DQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAVIFRVLQERDLLKTFQIPADTLLRYL
LTLEGHYHSNVAYHNSIHAADVVQSAHVLLGTPALEAVFTDLEVLAAIFACAIHDVDHPG
VSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQGENCDIFQNLSTKQKLSLRRMVID
MVLATDMSKHMSLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQSLVHCADLSNPAKPL
PLYRQWTERIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWAD
LVHPDAQELLDTLEDNREWYQSRVPCSPPHAIGPDRFKFELTLEETEEEEEEDERH
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|
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| BDBM10847 |
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| n/a |
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| Name | BDBM10847 |
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| Synonyms: | 1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione | 1,3-dimethyl-7H-purine-2,6-dione | Afonilum | Aminophyllin | Aminophylline | CHEMBL190 | Cardophyllin | Euphylline | Theophy-lline | Theophylline | Theophylline (1,3-dimethylxanthine) |
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| Type | Small organic molecule |
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| Emp. Form. | C7H8N4O2 |
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| Mol. Mass. | 180.164 |
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| SMILES | Cn1c2nc[nH]c2c(=O)n(C)c1=O |
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| Structure | 
|
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