| Reaction Details |
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 | Report a problem with these data |
| Target | Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1 |
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| Ligand | BDBM50003560 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_147491 (CHEMBL754238) |
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| IC50 | 2000±n/a nM |
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| Citation |  Mohacsi, E; Leimgruber, W; Baruth, H Synthesis and pharmacology of metabolically stable tert-butyl ethers of morphine and levorphanol. J Med Chem25:1264-6 (1982) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1 |
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| Name: | Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1 |
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| Synonyms: | Opioid receptor |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | ASSAY_ID of ChEMBL is 146137 |
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| Components: | This complex has 4 components. |
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| Component 1 |
| Name: | Sigma non-opioid intracellular receptor 1 |
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| Synonyms: | Opioid receptor, sigma 1 | Oprs1 | SGMR1_MOUSE | Sigma 1-type opioid receptor | Sigma1-receptor | Sigma1R | Sigmar1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 25246.51 |
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| Organism: | Mus musculus (Mouse) |
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| Description: | O55242 |
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| Residue: | 223 |
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| Sequence: | MPWAAGRRWAWITLILTIIAVLIQAAWLWLGTQNFVFSREEIAQLARQYAGLDHELAFSR
LIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCILHASLSEYVLLFGTALGSHGHSGRY
WAEISDTIISGTFHQWKEGTTKSEVFYPGETVVHGPGEATALEWGPNTWMVEYGRGVIPS
TLFFALADTFFSTQDYLTLFYTLRAYARGLRLELTTYLFGQDS
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| Component 2 |
| Name: | Mu-type opioid receptor |
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| Synonyms: | M-OR-1 | MOR-1 | Mor | OPIATE Mu | OPRM_MOUSE | Opioid receptors; mu and delta | Oprm | Oprm1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 44431.62 |
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| Organism: | MOUSE |
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| Description: | OPIATE Mu OPRM1 MOUSE::P42866 |
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| Residue: | 398 |
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| Sequence: | MDSSAGPGNISDCSDPLAPASCSPAPGSWLNLSHVDGNQSDPCGPNRTGLGGSHSLCPQT
GSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST
LPFQSVNYLMGTWPFGNILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRT
PRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFA
FIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYV
IIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQ
QNSARIRQNTREHPSTANTVDRTNHQLENLEAETAPLP
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| Component 3 |
| Name: | Kappa-type opioid receptor |
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| Synonyms: | KOR-1 | MSL-1 | OPIATE Kappa | OPRK_MOUSE | Oprk1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 42656.78 |
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| Organism: | Mus musculus (Mouse) |
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| Description: | P33534 |
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| Residue: | 380 |
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| Sequence: | MESPIQIFRGDPGPTCSPSACLLPNSSSWFPNWAESDSNGSVGSEDQQLESAHISPAIPV
IITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSAVYL
MNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINI
CIWLLASSVGISAIVLGGTKVREDVDVIECSLQFPDDEYSWWDLFMKICVFVFAFVIPVL
IIIVCYTLMILRLKSVRLLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALG
STSHSTAALSSYYFCIALGYTNSSLNPVLYAFLDENFKRCFRDFCFPIKMRMERQSTNRV
RNTVQDPASMRDVGGMNKPV
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| Component 4 |
| Name: | Delta-type opioid receptor |
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| Synonyms: | DOR-1 | K56 | MSL-2 | OPIATE Delta | OPRD_MOUSE | Opioid receptors; mu and delta | Oprd1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 40577.25 |
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| Organism: | MOUSE |
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| Description: | P32300 |
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| Residue: | 372 |
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| Sequence: | MELVPSARAELQSSPLVNLSDAFPSAFPSAGANASGSPGARSASSLALAIAITALYSAVC
AVGLLGNVLVMFGIVRYTKLKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELL
CKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVG
VPIMVMAVTQPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRL
RSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDINRRDPLVVAAL
HLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRTPCGRQEPGSLRRPRQATTRERVTAC
TPSDGPGGGAAA
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| BDBM50003560 |
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| n/a |
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| Name | BDBM50003560 |
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| Synonyms: | 4-methoxy-17-methyl-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-triene | 4-methoxy-17-methyl-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2,4,6-triene | CHEMBL22207 | Dextromethorphan | Levomethorpan |
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| Type | Small organic molecule |
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| Emp. Form. | C18H25NO |
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| Mol. Mass. | 271.3972 |
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| SMILES | COc1ccc2CC3C4CCCCC4(CCN3C)c2c1 |TLB:19:18:8:16.14.15,17:16:8:18.5.6| |
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| Structure | 
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