| Reaction Details |
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 | Report a problem with these data |
| Target | Amine oxidase [flavin-containing] A/B |
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| Ligand | BDBM50452531 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_122635 (CHEMBL731860) |
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| IC50 | 17000±n/a nM |
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| Citation |  Sahlberg, C; Ross, SB; Fagervall, I; Ask, AL; Claesson, A Synthesis and monoamine oxidase inhibitory activities of alpha-allenic amines in vivo and in vitro. Different activities of two enantiomeric allenes. J Med Chem26:1036-42 (1983) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Amine oxidase [flavin-containing] A/B |
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| Name: | Amine oxidase [flavin-containing] A/B |
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| Synonyms: | Monoamine oxidase |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | ASSAY_ID of ChEMBL is 122635 |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Amine oxidase [flavin-containing] B |
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| Synonyms: | AOFB_RAT | Amine oxidase (flavin-containing) B | Amine oxidase [flavin-containing] B | Maob | Monoamine Oxidase Type B (MAO-B) | Monoamine oxidase | Monoamine oxidase B (MAO-B) | Monoamine oxidase B (rMAO-B) | Monoamine oxidase type B (MAOB) | Monoamine oxidase-B (MAO-B) |
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| Type: | Enzyme |
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| Mol. Mass.: | 58469.65 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | P19643 |
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| Residue: | 520 |
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| Sequence: | MSNKCDVIVVGGGISGMAAAKLLHDCGLSVVVLEARDRVGGRTYTIRNKNVKYVDLGGSY
VGPTQNRILRLAKELGLETYKVNEVERLIHFVKGKSYAFRGPFPPVWNPITYLDYNNLWR
TMDEMGQEIPSDAPWKAPLAEEWDYMTMKELLDKICWTNSTKQIATLFVNLCVTAETHEV
SALWFLWYVKQCGGTTRIISTTNGGQERKFIGGSGQVSERIKDILGDRVKLERPVIHIDQ
TGENVVVKTLNHEIYEAKYVISAIPPVLGMKIHHSPPLPILRNQLITRVPLGSVIKCMVY
YKEPFWRKKDFCGTMVIEGEEAPIAYTLDDTKPDGSCAAIMGFILAHKARKLVRLTKEER
LRKLCELYAKVLNSQEALQPVHYEEKNWCEEQYSGGCYTAYFPPGILTQYGRVLRQPVGK
IFFAGTETASHWSGYMEGAVEAGERAAREILHAIGKIPEDEIWQPEPESVDVPARPITNT
FLERHLPSVPGLLKLLGLTTILSATALGFLAHKKGLFVRF
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| Component 2 |
| Name: | Amine oxidase [flavin-containing] A |
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| Synonyms: | AOFA_RAT | Amine oxidase (flavin-containing) A | Amine oxidase [flavin-containing] A | Maoa | Monoamine Oxidase Type A (MAO-A) | Monoamine oxidase | Monoamine oxidase A (MAO-A) | Monoamine oxidase A (rMAO-A) | Monoamine oxidase type A (MAOA) |
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| Type: | Enzyme |
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| Mol. Mass.: | 59515.21 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | n/a |
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| Residue: | 526 |
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| Sequence: | MTDLEKPNLAGHMFDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHV
KWVDVGGAYVGPTQNRILRLSKELGIETYKVNVNERLVQYVKGKTYPFRGAFPPVWNPLA
YLDYNNLWRTMDEMGKEIPVDAPWQARHAQEWDKMTMKDLIDKICWTKTAREFAYLFVNI
NVTSEPHEVSALWFLWYVRQCGGTARIFSVTNGGQERKFVGGSGQVSEQIMGLLGDKVKL
SSPVTYIDQTDDNIIVETLNHEHYECKYVISAIPPILTAKIHFKPELPPERNQLIQRLPM
GAVIKCMVYYKEAFWKKKDYCGCMIIEDEEAPIAITLDDTKPDGSLPAIMGFILARKADR
QAKLHKDIRKRKICELYAKVLGSQEALYPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYG
RVIRQPVGRIYFAGTETATQWSGYMEGAVEAGERAAREVLNALGKVAKKDIWVEEPESKD
VPAIEITHTFLERNLPSVPGLLKITGVSTSVALLCFVLYKIKKLPC
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| BDBM50452531 |
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| n/a |
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| Name | BDBM50452531 |
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| Synonyms: | CHEMBL2028089 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H19NO4 |
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| Mol. Mass. | 277.3157 |
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| SMILES | OC(=O)C(O)=O.CC=C=CCN(C)Cc1ccccc1 |(21.28,-8.31,;19.74,-8.31,;18.97,-6.98,;18.97,-9.64,;17.43,-9.64,;19.74,-10.98,;19.44,-4.47,;18.11,-3.7,;16.61,-4.07,;15.12,-4.46,;13.79,-3.65,;12.45,-4.41,;11.12,-3.62,;12.42,-5.95,;11.08,-6.7,;9.76,-5.91,;8.41,-6.66,;8.39,-8.2,;9.72,-8.99,;11.05,-8.23,)| |
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| Structure | 
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