Reaction Details |
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Target | Dihydrofolate reductase |
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Ligand | BDBM50405086 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_54084 (CHEMBL669981) |
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Ki | 154882±n/a nM |
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Citation | Hathaway, BA; Guo, ZR; Hansch, C; Delcamp, TJ; Susten, SS; Freisheim, JH Inhibition of human dihydrofolate reductase by 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(substituted-phenyl)-s-triazine s. A quantitative structure-activity relationship analysis. J Med Chem27:144-9 (1984) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Dihydrofolate reductase |
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Name: | Dihydrofolate reductase |
Synonyms: | DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase |
Type: | Enzyme |
Mol. Mass.: | 21453.99 |
Organism: | Homo sapiens (Human) |
Description: | Recombinant human DHFR. |
Residue: | 187 |
Sequence: | MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
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BDBM50405086 |
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n/a |
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Name | BDBM50405086 |
Synonyms: | CHEMBL428478 |
Type | Small organic molecule |
Emp. Form. | C11H16N6O2S |
Mol. Mass. | 296.349 |
SMILES | CC1(C)N=C(N)N=C(N)N1c1ccc(cc1)S(N)(=O)=O |t:3,6| |
Structure |
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