Reaction Details |
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Target | Dihydrofolate reductase type 1 |
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Ligand | BDBM50405065 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_54572 (CHEMBL664886) |
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Ki | 398107171±n/a nM |
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Citation | Coats, EA; Genther, CS; Selassie, CD; Strong, CD; Hansch, C Quantitative structure-activity relationship of antifolate inhibition of bacteria cell cultures resistant and sensitive to methotrexate. J Med Chem28:1910-6 (1985) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Dihydrofolate reductase type 1 |
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Name: | Dihydrofolate reductase type 1 |
Synonyms: | DYR1_ECOLX | dhfrI |
Type: | PROTEIN |
Mol. Mass.: | 17574.87 |
Organism: | Escherichia coli |
Description: | ChEMBL_54248 |
Residue: | 157 |
Sequence: | MKLSLMVAISKNGVIGNGPDIPWSAKGEQLLFKAITYNQWLLVGRKTFESMGALPNRKYA
VVTRSSFTSDNENVLIFPSIKDALTNLKKITDHVIVSGGGEIYKSLIDQVDTLHISTIDI
EPEGDVYFPEIPSNFRPVFTQDFASNINYSYQIWQKG
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BDBM50405065 |
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n/a |
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Name | BDBM50405065 |
Synonyms: | CHEMBL286571 |
Type | Small organic molecule |
Emp. Form. | C19H23N5S |
Mol. Mass. | 353.484 |
SMILES | Cc1cccc(SCc2cccc(c2)N2C(N)=NC(N)=NC2(C)C)c1 |c:17,20| |
Structure |
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