Reaction Details | |||
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Target | Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1 | ||
Ligand | BDBM50225942 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_146277 (CHEMBL756522) | ||
EC50 | 90±n/a nM | ||
Citation | Lessor, RA; Bajwa, BS; Rice, KC; Jacobson, AE; Streaty, RA; Klee, WA; Smith, CB; Aceto, MD; May, EL; Harris, LS Probes for narcotic receptor mediated phenomena. 13. Potential irreversible narcotic antagonist-based ligands derived from 6,14-endo-ethenotetrahydronororipavine with 7-(methoxyfumaroyl)amino, (bromoacetyl)amino, or isothiocyanate electrophiles: chemistry, biochemistry, and pharmacology. J Med Chem29:2136-41 (1986) [PubMed] | ||
More Info.: | Get all data from this article, Assay Method | ||
Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1 | |||
Name: | Delta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1 | ||
Synonyms: | Opioid receptor | ||
Type: | n/a | ||
Mol. Mass.: | n/a | ||
Description: | ASSAY_ID of ChEMBL is 172778 | ||
Components: | This complex has 4 components. | ||
Component 1 | |||
Name: | Mu-type opioid receptor | ||
Synonyms: | MOR-1 | MUOR1 | Mu-type opioid receptor (MOR) | OPIATE Mu | OPRM_RAT | Opiate non-selective | Opioid receptor B | Oprm1 | Ror-b | ||
Type: | G Protein-Coupled Receptor (GPCR) | ||
Mol. Mass.: | 44503.11 | ||
Organism: | Rattus norvegicus (rat) | ||
Description: | Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the mu opioid receptor. | ||
Residue: | 398 | ||
Sequence: |
| ||
Component 2 | |||
Name: | Sigma non-opioid intracellular receptor 1 | ||
Synonyms: | Opioid receptor | Oprs1 | SGMR1_RAT | Sigma | Sigma non-opioid intracellular receptor 1 | Sigma opioid receptor | Sigma-1 | Sigmar1 | ||
Type: | Enzyme Catalytic Domain | ||
Mol. Mass.: | 25266.54 | ||
Organism: | RAT | ||
Description: | Q9R0C9 | ||
Residue: | 223 | ||
Sequence: |
| ||
Component 3 | |||
Name: | Kappa-type opioid receptor | ||
Synonyms: | KOR-1 | Kappa Opioid Receptor | OPIATE Kappa | OPRK_RAT | Opioid receptor | Oprk1 | Ror-d | ||
Type: | G Protein-Coupled Receptor (GPCR) | ||
Mol. Mass.: | 42692.90 | ||
Organism: | Rattus norvegicus (rat) | ||
Description: | P34975 | ||
Residue: | 380 | ||
Sequence: |
| ||
Component 4 | |||
Name: | Delta-type opioid receptor | ||
Synonyms: | Cytochrome P450 3A4 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor | Delta-type opioid receptor (DOR) | OPIATE Delta | OPRD_RAT | Opiate Delta 1 | Opioid receptor | Opioid receptor A | Opioid receptors; mu & delta | Oprd1 | Ror-a | Voltage-gated potassium channel | ||
Type: | G Protein-Coupled Receptor (GPCR) | ||
Mol. Mass.: | 40465.04 | ||
Organism: | Rattus norvegicus (rat) | ||
Description: | Competition binding assays were using CHO-K1 cell membranes expressing the opioid receptor. | ||
Residue: | 372 | ||
Sequence: |
| ||
BDBM50225942 | |||
n/a | |||
Name | BDBM50225942 | ||
Synonyms: | CHEMBL2310916 | ||
Type | Small organic molecule | ||
Emp. Form. | C29H32N2O10 | ||
Mol. Mass. | 568.5718 | ||
SMILES | OC(=O)C(O)=O.[H][C@@]12Oc3c4c(C[C@@]5([H])N(CC=C)CC[C@@]14[C@]51C[C@H](NC(=O)\C=C\C(=O)OC)C2(OC)C=C1)ccc3O |r,wU:22.24,21.19,7.5,wD:24.26,13.12,c:40,THB:25:24:21.7:38.37,16:15:22:10.11.12,(1.76,5.46,;2.53,4.13,;4.07,4.13,;1.76,2.8,;.22,2.8,;2.53,1.46,;-9.74,-.57,;-7.91,-.19,;-8.68,1.56,;-7.91,2.89,;-6.58,2.12,;-5.25,2.89,;-3.91,2.12,;-3.91,.58,;-2.3,1.51,;-2.58,-.19,;-2.18,-1.68,;-.69,-2.08,;-.29,-3.56,;-2.58,1.35,;-5.49,1.67,;-6.58,.58,;-5.25,-.19,;-5.25,-1.73,;-6.58,-2.5,;-6.58,-4.04,;-5.25,-4.81,;-3.91,-4.04,;-5.25,-6.35,;-3.76,-6.75,;-3.36,-8.24,;-4.45,-9.32,;-1.87,-8.63,;-1.47,-10.12,;-7.91,-1.73,;-9.25,-2.5,;-9.25,-4.04,;-6.34,-2.08,;-6.73,-.59,;-5.25,4.43,;-6.58,5.2,;-7.91,4.43,;-9.25,5.2,)| | ||
Structure |