Reaction Details |
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Target | Dihydrofolate reductase |
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Ligand | BDBM50227266 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_54731 |
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Ki | 0.977237±n/a nM |
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Citation | Li, RL; Poe, M Quantitative structure-activity relationships for the inhibition of Escherichia coli dihydrofolate reductase by 5-(substituted benzyl)-2,4-diaminopyrimidines. J Med Chem31:366-70 (1988) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Dihydrofolate reductase |
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Name: | Dihydrofolate reductase |
Synonyms: | Dihydrofolate reductase (F31V) | dfrA17 |
Type: | n/a |
Mol. Mass.: | 17532.46 |
Organism: | Escherichia coli |
Description: | n/a |
Residue: | 157 |
Sequence: | MKISLISAVSESGVIGSGPDIPWSVKGEQLLFKALTYNQWLLVGRKTFDSMGVLPNRKYA
VVSKNGISSSNENVLVFPSIENALKELSKVTDHVYVSGGGQIYNSLIEKADIIHLSTVHV
EVEGDIKFPIMPENFNLVFEQFFMSNINYTYQIWKKG
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BDBM50227266 |
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n/a |
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Name | BDBM50227266 |
Synonyms: | CHEMBL332237 |
Type | Small organic molecule |
Emp. Form. | C16H22N4O2 |
Mol. Mass. | 302.3715 |
SMILES | CCCCOc1ccc(Cc2cnc(N)nc2N)cc1OC |
Structure |
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