| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM50227443 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_54735 (CHEMBL667186) |
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| Ki | 0.589±n/a nM |
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| Citation |  Doweyko, AM The hypothetical active site lattice. An approach to modelling active sites from data on inhibitor molecules. J Med Chem31:1396-406 (1988) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | Dihydrofolate reductase (F31V) | dfrA17 |
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| Type: | n/a |
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| Mol. Mass.: | 17532.46 |
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| Organism: | Escherichia coli |
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| Description: | n/a |
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| Residue: | 157 |
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| Sequence: | MKISLISAVSESGVIGSGPDIPWSVKGEQLLFKALTYNQWLLVGRKTFDSMGVLPNRKYA
VVSKNGISSSNENVLVFPSIENALKELSKVTDHVYVSGGGQIYNSLIEKADIIHLSTVHV
EVEGDIKFPIMPENFNLVFEQFFMSNINYTYQIWKKG
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|
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| BDBM50227443 |
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| n/a |
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| Name | BDBM50227443 |
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| Synonyms: | CHEMBL418763 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H17BrN4O4 |
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| Mol. Mass. | 397.224 |
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| SMILES | COc1cc(Cc2cnc(N)nc2N)cc(OCCC(O)=O)c1Br |
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| Structure | 
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