| Reaction Details |
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 | Report a problem with these data |
| Target | cAMP-specific 3',5'-cyclic phosphodiesterase 4C |
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| Ligand | BDBM50229038 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_157210 (CHEMBL768861) |
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| IC50 | 3.2±n/a nM |
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| Citation |  Lowe, JA; Archer, RL; Chapin, DS; Chen, JB; Helweg, D; Johnson, JL; Koe, BK; Lebel, LA; Moore, PF; Nielsen, JA Structure-activity relationship of quinazolinedione inhibitors of calcium-independent phosphodiesterase. J Med Chem34:624-8 (1991) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| cAMP-specific 3',5'-cyclic phosphodiesterase 4C |
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| Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4C |
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| Synonyms: | Dpde1 | PDE4C_RAT | Pde4c |
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| Type: | PROTEIN |
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| Mol. Mass.: | 60038.21 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_104732 |
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| Residue: | 536 |
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| Sequence: | NSSRTSSAASDLHGEDMIVTPFAQVLASLRTVRSNVAALAHGAGSATRQALLGTPPQSSQ
QAAPAEESGLQLAQETLEELDWCLEQLETLQTRRSVGEMASNKFKRMLNRELTHLSETSR
SGNQVSEYISQTFLDQQAEVELPAPPTEDHPWPMAQITGLRKSCHTSLPTAAIPRFGVQT
DQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAVIFRVLQERDLLKTFQIPADTLLRYL
LTLEGHYHSNVAYHNSIHAADVVQSAHVLLGTPALEAVFTDLEVLAAIFACAIHDVDHPG
VSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQGENCDIFQNLSTKQKLSLRRMVID
MVLATDMSKHMSLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQSLVHCADLSNPAKPL
PLYRQWTERIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWAD
LVHPDAQELLDTLEDNREWYQSRVPCSPPHAIGPDRFKFELTLEETEEEEEEDERH
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| BDBM50229038 |
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| n/a |
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| Name | BDBM50229038 |
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| Synonyms: | CHEMBL345917 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H23N3O4 |
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| Mol. Mass. | 405.4464 |
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| SMILES | COC(=O)c1cccc(c1)-n1c2ncccc2c(=O)n(CC2CC3CCC2C3)c1=O |THB:20:21:27:25.24| |
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| Structure | 
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