| Reaction Details |
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 | Report a problem with these data |
| Target | Carbonic anhydrase 6 |
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| Ligand | BDBM10880 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_47171 (CHEMBL877290) |
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| IC50 | 72±n/a nM |
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| Citation |  Lo, YS; Nolan, JC; Maren, TH; Welstead, WJ; Gripshover, DF; Shamblee, DA Synthesis and physicochemical properties of sulfamate derivatives as topical antiglaucoma agents. J Med Chem35:4790-4 (1992) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Carbonic anhydrase 6 |
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| Name: | Carbonic anhydrase 6 |
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| Synonyms: | CA-VI | CA6 | CAH6_BOVIN | Carbonate dehydratase VI | Carbonic anhydrase 6 | Carbonic anhydrase VI | Salivary carbonic anhydrase | Secreted carbonic anhydrase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 37008.14 |
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| Organism: | Bos taurus |
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| Description: | ChEMBL_104851 |
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| Residue: | 319 |
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| Sequence: | MITLLFLLVVGAQAQHEWTYSEGVLDEKHWRLQYPDCGGTRQSPIDLKMKKVRYNPSLRA
LNLTGYGLRQGEFPMTNNGHTVQISLPSSMRMTTSDGSQYLAKQMHFHWGGDSSEISGSE
HTVDGMRYIIEIHVVHYHSKYGSYEEAQNEPDGLAVLAALVEVKDYAENTYYSNFISHLE
DIRYAGQSTVLRDLDIQDMLPGDLRYYYSYLGSLTTPSCTENVHWFVVADTVKLSKTQIE
KLENSLLNHQNETIQNNYRSTQPLNHRVVEANFVSHPHQEYTLGSKLHFYLNNIDQNLEY
LRRFIEQKITKRKKEKYWP
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| BDBM10880 |
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| n/a |
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| Name | BDBM10880 |
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| Synonyms: | AZA | AZA2 | AZM acetazolamide | Acerazolamide, AAZ | Acetazolamide | Acetazolamide (AAZ) | Acetazolamide (AZA) | Acetazolamide (AZM) | Acetazolamide, 5 | Acetazolamide, AAZ | Acetazolamide, AZA | Acetazolamide, AZM | CHEMBL20 | N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide | Sulfonamide, 1 | US10172837, Acetazolamide | US11278534, Example acetazolamide | US11535599, Example acetazolamide | sulfonamide 1 |
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| Type | Small organic molecule |
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| Emp. Form. | C4H6N4O3S2 |
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| Mol. Mass. | 222.245 |
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| SMILES | CC(=O)Nc1nnc(s1)S(N)(=O)=O |
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| Structure | 
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