| Reaction Details |
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 | Report a problem with these data |
| Target | Carbonic anhydrase 4 |
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| Ligand | BDBM50231538 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1645380 (CHEMBL3994309) |
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| Ki | 7.5±n/a nM |
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| Citation |  Krasavin, M; Korsakov, M; Zvonaryova, Z; Semyonychev, E; Tuccinardi, T; Kalinin, S; Tanç, M; Supuran, CT Human carbonic anhydrase inhibitory profile of mono- and bis-sulfonamides synthesized via a direct sulfochlorination of 3- and 4-(hetero)arylisoxazol-5-amine scaffolds. Bioorg Med Chem25:1914-1925 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Carbonic anhydrase 4 |
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| Name: | Carbonic anhydrase 4 |
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| Synonyms: | CA-IV | CA4 | CAH4_HUMAN | Carbonate dehydratase IV | Carbonic anhydrase | Carbonic anhydrase 4 (CA IV) | Carbonic anhydrase IV (CA IV) |
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| Type: | Enzyme |
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| Mol. Mass.: | 35037.98 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P22748 |
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| Residue: | 312 |
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| Sequence: | MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTK
AKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSD
LPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGF
QPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFRE
PIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLG
PMLACLLAGFLR
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| BDBM50231538 |
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| n/a |
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| Name | BDBM50231538 |
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| Synonyms: | CHEMBL4102368 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H15N3O4S |
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| Mol. Mass. | 309.341 |
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| SMILES | CC(=O)Nc1onc(C)c1-c1ccc(C)c(c1)S(N)(=O)=O |
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| Structure | 
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