Reaction Details |
| Report a problem with these data |
Target | Protein mono-ADP-ribosyltransferase PARP3 |
---|
Ligand | BDBM27135 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1646306 (CHEMBL3995362) |
---|
IC50 | 2040±n/a nM |
---|
Citation | Thorsell, AG; Ekblad, T; Karlberg, T; Löw, M; Pinto, AF; Trésaugues, L; Moche, M; Cohen, MS; Schüler, H Structural Basis for Potency and Promiscuity in Poly(ADP-ribose) Polymerase (PARP) and Tankyrase Inhibitors. J Med Chem60:1262-1271 (2017) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Protein mono-ADP-ribosyltransferase PARP3 |
---|
Name: | Protein mono-ADP-ribosyltransferase PARP3 |
Synonyms: | ADP-ribosyltransferase diphtheria toxin-like 3 | ADPRT-3 | ADPRT3 | ADPRTL3 | ARTD3 | IRT1 | NAD(+) ADP-ribosyltransferase 3 | PARP-3 | PARP3 | PARP3_HUMAN | Poly [ADP-ribose] polymerase 3 | Poly[ADP-ribose] synthase 3 | hPARP-3 | pADPRT-3 |
Type: | PROTEIN |
Mol. Mass.: | 60091.40 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_109545 |
Residue: | 533 |
Sequence: | MAPKPKPWVQTEGPEKKKGRQAGREEDPFRSTAEALKAIPAEKRIIRVDPTCPLSSNPGT
QVYEDYNCTLNQTNIENNNNKFYIIQLLQDSNRFFTCWNRWGRVGEVGQSKINHFTRLED
AKKDFEKKFREKTKNNWAERDHFVSHPGKYTLIEVQAEDEAQEAVVKVDRGPVRTVTKRV
QPCSLDPATQKLITNIFSKEMFKNTMALMDLDVKKMPLGKLSKQQIARGFEALEALEEAL
KGPTDGGQSLEELSSHFYTVIPHNFGHSQPPPINSPELLQAKKDMLLVLADIELAQALQA
VSEQEKTVEEVPHPLDRDYQLLKCQLQLLDSGAPEYKVIQTYLEQTGSNHRCPTLQHIWK
VNQEGEEDRFQAHSKLGNRKLLWHGTNMAVVAAILTSGLRIMPHSGGRVGKGIYFASENS
KSAGYVIGMKCGAHHVGYMFLGEVALGREHHINTDNPSLKSPPPGFDSVIARGHTEPDPT
QDTELELDGQQVVVPQGQPVPCPEFSSSTFSQSEYLIYQESQCRLRYLLEVHL
|
|
|
BDBM27135 |
---|
n/a |
---|
Name | BDBM27135 |
Synonyms: | 2-[(2R)-2-methylpyrrolidin-2-yl]-1H-1,3-benzodiazole-4-carboxamide | VELIPARIB | benzimidazole carboxamide, 3a |
Type | Small organic molecule |
Emp. Form. | C13H16N4O |
Mol. Mass. | 244.2923 |
SMILES | C[C@@]1(CCCN1)c1nc2cccc(C(N)=O)c2[nH]1 |r| |
Structure |
|