| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Serine/threonine-protein kinase pim-3 |
|---|
| Ligand | BDBM50232778 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1648575 (CHEMBL3997631) |
|---|
| IC50 | 0.400000±n/a nM |
|---|
| Citation |  Nakano, H; Hasegawa, T; Kojima, H; Okabe, T; Nagano, T Design and Synthesis of Potent and Selective PIM Kinase Inhibitors by Targeting Unique Structure of ATP-Binding Pocket. ACS Med Chem Lett8:504-509 (2017) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Serine/threonine-protein kinase pim-3 |
|---|
| Name: | Serine/threonine-protein kinase pim-3 |
|---|
| Synonyms: | PIM3 | PIM3_HUMAN | Serine/threonine-protein kinase pim-3 (PIM3) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 35888.19 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q86V86 |
|---|
| Residue: | 326 |
|---|
| Sequence: | MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRI
ADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFL
LVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDL
RSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVC
GDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGGV
PESCDLRLCTLDPDDVASTTSSSESL
|
|
|
|---|
| BDBM50232778 |
|---|
| n/a |
|---|
| Name | BDBM50232778 |
|---|
| Synonyms: | CHEMBL4062256 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H21ClN4O3 |
|---|
| Mol. Mass. | 424.88 |
|---|
| SMILES | COc1ccc2C(=O)\C(Oc2c1CN1CCNCC1)=C\c1c[nH]c2nc(Cl)ccc12 |
|---|
| Structure | 
|
|---|
Search and Browse
